Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know
remaining cards
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

immunology quiz 4

immunology quiz 4 - CLLS-316

ASO individual test for anti-streptolysin O, neutralization procedure
Streptolyzyme kit tests for anti-streptolysin O, anti-DNASE, anti-hyaluronidise, & anti-streptokinase
HIV types of testing western blot, Gp24 antigen test, CD4 Tcells, viral load testing
Streptococcal testing ASO and Streptozyme
Western blot gold standard/confirmation
Gp24 antigen testing donors
Epstein Barr Paul Bunnell, heterophile antibody, Anti-VCA, EA, EBNA
Autoimmune diseases occur from breakdown of Self-tolerance maybe systematic or organ specific
SLE - Systemic lupus erythematosus antibody=anti-DNA-many type systemic disease of chronic inflammation alternating exacerbations and remissions Diagnostic - butterfly rash, LE cells ANA test, FANA test - basic principle
RA - Rheumatoid Arthritis antibody= IgM against Fc portion of IgG - IgM/IgG complexes degenerative joint disease - systemic lab testing - Latex agglutination for Rheumatoid factor
MG - Myasthenia Gravis neuromuscular, antibody to ACH receptors causes fatigue of skeletal muscles
MS - Multiple Sclerosis T cells attack myelin, B cells produce anti-myelin antibodies demyelating disease of CNS lab testing - IgG index, Immunologic tests for anti-myelin antibodies
Grave's disease TSI - Thyroid stimulating immunoglobulin "bulging eyes",diffuse goiter,hyperthyroidism
Hashimoto's disease antithyroglobulin antibodies, hypothyroidism, goiter
Type I diabetes mellitus Islet antibodies - against Beta cells of the Islets of Langerhans in the pancreas Cause lack of insulin production and hyperglycemia might be triggered by Coxsackie virus
Hypersensitivity has 2 phases Sensitization and Effector and has 4 types
Sensitization first exposure, exposure to small amount of antigen
effector second exposure to antigen
Type I (Atopic & Anaphylactic)Hypersensitivity IgE mediated, mast cells release granules, anaphalaxis, Wheal and Flare reaction, Lab tests - RAST, in vivo skin tests
Type II (cytotoxic)Hypersensitivity IgG or IgM mediated, activates complement, hemolytic reactions - transfusion,HDN, autoimmune Lab testing - DAT
Type III (immune complex)Hypersensitivity IgG or IgM mediated, activates complement, soluble antigen, arthus, serum sickness Lab tests - latex agglutination, fluorescent staining
Type IV (T cell dependent)Hypersensitivity delayed hypersensitivity, immunoglobulin and complement not involved, T-cells and macrophages mediate, PPD test - mantoux skin test
Immunoproliferative diseases defect in regulation - malignancies - lymphoma, leukemia, multiple myeloma, Waldenstroms
Immunodeficiencies Neutrophillic defects - CGD - oxygen deficient for killing -NBT test Leukocyte Adhesion - CD 11 and CD 18 proteins
Goodpasture's syndrome noncollagenous protein in basement membranes of kidney glomeruli and lung alveoli. complement & Fc receptor-mediated inflammation. Nephritis, lung hemorrhages.
Pernicious anemia Neutralization of intrinsic factor, decreased absorption of vitamin B12. Abnormal erythropoiesis, anemia
Autoimmune hemolytic anemia opsonization & phagocytosis of erythrocytes, hemolysis and anemia
Autoimmune(Idiopathic) thrombocytopenic purpura opsonization & phagocytosis of platelets, bleeding.
pemphigus vulgaris antibody-mediated activation of proteases, disruption of intercellular adhesions, skin vesicles (bullae)
NBT - nitroblue tetrazoliun the dye that neutrophil's reduce. How to diagnose CGD.
malignancy excess accumulation of cells, failure to regulate, chromosome mutations.
Lymphocyte malignancies lymphomas and leukemias
Lymphoma Hodgkin's and Non-Hodgkins
Leukemia acute and chronic
Hodgkin's Lymphoma presence of Reed Sternberg cells, highly treatable, often curable, young adults & elderly
Non-Hodgkin's Lymphoma B cell lymphoma (85%), T cell lymphomas
ALL - Acute Lymphocytic Leukemia poorly differentiated precursor cells (blast), can be divided in types T cell, B cell, non T/non B cell
CLL - Chronic Lymphocytic Leukemia/Lymphoma almost exclusively B cell origin, CLL, PLL, HCL
Plasma Cellulinemia Malignancies Multiple Myeloma, Waldenstrom's Macroglobulinemia
Multiple Myeloma malignancy of mature plasma cells, produce paraproteins
Waldenstrom's Macroglobulinemia malignant proliferation of IgM-producing lymphocytes, produce paraproteins
Hep A Serology RNA virus- Picornovirus, oral-fecal, presence of IgM antibodies(acute), most often detected by ELISA
Created by: pamela18