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Phys Exam 2: Ch 17
Local control of tissue blood flow
Question | Answer |
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Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: An increase in PCO2 in the tissue | Increase |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: An increase in PO2 in the tissue | Decrease |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: Norepinephrine-mediated stimulation of alpha-1-adrenergic receptors expressed on the smooth muscle cells of the vasculature that feeds the tissue | Decrease |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: An increase in intracellular ATP concentrations in the tissue | Decrease |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: Opening of stretch-operated channels expressed on smooth muscle cells of the vasculature that feeds the tissue | Decrease |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: Release of endothelin from endothelial cells of a damaged blood vessel that feeds the tissue | Decrease |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: Release of nitric oxide (NO) from endothelial cells of an intact blood vessel that feeds the tissue | Increase |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: Norepinephrine-mediated stimulation of beta-2-adrenergic receptors expressed on the smooth muscle cells of the vasculature that feeds skeletal muscle | Increase |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: An increase in extracellular adenosine in the tissue | Increase |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: A decrease in pH in the tissue | Increase |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: A decrease in PO2 in the tissue | Increase |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: A decrease in lactic acid production in the tissue | Decrease |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: A decrease in intracellular ATP concentrations in the tissue | Increase |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: Stimulation of Gq-coupled receptors expressed on smooth muscle cells of the vasculature that feeds the tissu | Decrease |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: Activation of Protein Kinase A in the smooth muscle cells of the vasculature that feeds the tissue | Increase |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: Activation of eNOS in the endothelial cells of the vasculature that feeds the tissue | Increase |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: A decrease in PCO2 in the tissue | Decrease |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: An increase in cytosolic Ca2+ levels in smooth muscle cells of the vasculature that feeds the tissue | Decrease |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: Angiogenesis in the tissue | |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: Activation of Protein Kinase G in smooth muscle cells of the vasculature that feeds the tissue | Increase |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: Elevated levels of cGMP in smooth muscle cells of the vasculature that feeds the tissue | Increase |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: Inactivation of myosin light chain kinase in smooth muscle cells of the vasculature that feeds the tissue | Increase |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: An increase in the pre-capillary resistance of an arteriole that feeds the tissue capillary bed | Decrease |
Determine if the following will an increase, a decrease, or have no effect on blood flow to a tissue: Hyperpolarization of the membrane of smooth muscle cells of the vasculature that feeds the tissue | Increase |
Name three factors that can cause release of vasodilators from endothelial cells | |
Name a stimulus for release of endothelin from endothelial cells | ECs lining a blood vessel are damaged |
Outline the mechanism of action of nitric oxide | 1.Damage causes release of endothelin 2.Endothelin stimulates Gq-coupled endothelin receptors on vascular smooth muscle cells 3.Gq --> PLC --> IP3 --> cytosolic Ca2+ 4.Increased cytosolic Ca2+ stimulates smooth muscle contraction --> vasoconstriction |
TRUE or FALSE: A compound that inhibits alpha-1 adrenergic receptors will most likely cause an increase pre-capillary resistance | |
TRUE or FALSE: A compound that stimulates nitric oxide release from endothelial cells causes vasoconstriction | FALSE - vasodilation |
TRUE or FALSE: An increase in systemic arterial pressure causes a sustained increase in blood flow to all tissues | |
TRUE or FALSE: The amount of blood flow to a tissue is independent of the metabolic demands of that tissue | FALSE |
TRUE or FALSE: Damaged endothelial cells are more likely to release compounds that will cause vasoconstriction at the injury site | TRUE |
TRUE or FALSE: The major determinant of blood flow to a capillary bed under normal physiologic conditions is the post-capillary resistance (Rpost) | |
TRUE or FALSE: The walls of capillaries are composed primarily of smooth muscle cells | |
TRUE or FALSE: As the metabolic demand of a tissue increases, blood flow to that tissue remains constant because of autoregulation | |
TRUE or FALSE: Angiogenesis is a pathological phenomenon that does not occur under normal physiologic conditions | FALSE |
TRUE or FALSE: Sildenafil is useful in the treatment of erectile dysfunction because it promotes the breakdown of cGMP | FALSE - inhibits |
TRUE or FALSE: During vasomotion, an increase in PO2 in a tissue stimulates vasodilation, while a subsequent decrease in tissue PO2 stimulates vasoconstriction | FALSE – increase = vasoconstriction; decrease = vasodilation |
TRUE or FALSE: Vasoconstriction of a blood vessel requires nervous stimulation | FALSE |
TRUE or FALSE: A vasodilator may act by inhibiting the activity of myosin light chain kinase in smooth muscle cells | TRUE |
TRUE or FALSE: Activation of VEGF receptors stimulates proliferation and migration of endothelial cells | |
TRUE or FALSE: Autoregulation is the result of sympathetic stimulation of vascular smooth muscle | |
Determine if the following would be expected to cause VASODILATION or VASOCONSTRICTION of vascular smooth muscle: Norepinephrine (acting at alpha-1-adrenergic receptors) | VASOCONSTRICTION |
Determine if the following would be expected to cause VASODILATION or VASOCONSTRICTION of vascular smooth muscle: Histamine (acting at H2-type histamine receptors) | VASODILATION |
Determine if the following would be expected to cause VASODILATION or VASOCONSTRICTION of vascular smooth muscle: Ang II | VASOCONSTRICTION |
Determine if the following would be expected to cause VASODILATION or VASOCONSTRICTION of vascular smooth muscle: Bradykinin | VASODIATION |
Determine if the following would be expected to cause VASODILATION or VASOCONSTRICTION of vascular smooth muscle: Epinephrine (acting at beta-2-adrenergic receptors) | VASODILATION |
Determine if the following would be expected to cause VASODILATION or VASOCONSTRICTION of vascular smooth muscle: Vasopressin | VASOCONSTRICTION |
Determine if the following would be expected to cause VASODILATION or VASOCONSTRICTION of vascular smooth muscle: Nitroglycerin | VASODILATION |
Determine if the following would be expected to cause VASODILATION or VASOCONSTRICTION of vascular smooth muscle: Silendafil | VASODILATION |