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Hematology Final

What is the most useful corrective action for the microscope when fine details cannot be visualized in immature cells? use 100x and open diaphragm
Behaviors that are violations of standard precautions: not treating everyone as infected
Standard and calibrators differ from control materials because: -Standards are solutions that have a known amount of analyte and used to calibrate the instrument -controls are used to monitor the performance after calibration (mimics patient samples) -
Proper mixing of samples and timely delivery of samples to the lab are both examples of what type of lab variables preanalytical
A delta check is a historical reference on samples run in the lab. Once a sample fails a delta check, the most obvious corrective action is to Verify patient ID
Common examples of post analytic variables include -Delta check -results released -critical results called - reflex testing initiated - specimen checked for clots
Error analysis, standard protocols, and turnaround time are all part of the QA
The avg of a group of data points is defined as the mean
The avg M:E ration for normal adult bone marrow is 3:1 to 4:1
The key organs involved in extramedullary hematopoiesis include: Liver and spleen
The best test to assess the bone marrow's response to anemic stress is reticulocyte count
Antibody-coated red cells that have their antibodies stripped in the spleen usually reappear in the circulation as: spherocyte
A peripheral blood indicator of ineffective bone marrow is lack of polychromasia
The hormone responsible for signaling red cell development in the bone marrow is EPO (erythropoietin)
The preferable site for bone marrow aspiration and biopsy is iliac creast
A wright-stained smear of a patient with an elevated reticulocyte count should show Lg red-bluish cells, polychromatophilic macrocytes
One of the key morphological features of the nucleated red cell stage is baseball round nucleus
The red cell protein that is responsible for deform-ability and flexibility of the red cell is spectrin and ankryin
Increased plasma cholesterol may lead to the development of which abnormal red cell morphologies target cells
The hemoglobin molecule consists of 4 heme molecules, 4 golbin chains (2 pairs)
The basic pathophysiology of the thalassemic conditions is alpa genes are deleted beta genes are defective
Asynchrony in the bone marrow is defined as unbalanced heme; N:C age do not correspond
Polychromatophillic macrocytes in the perioheral smear are defined as reticulocytes
The red cell inclusion derived from denatured hemoglobin is heinz bodies
The degree of effective erythropoietic activity in any hematological disorder is most readily assessed by the reticulocyte count
Which red cell morphology will be produced when hemolysis is produced by intravascular fragmentation of red cells shistocyte
Reversible sickled cells are described as having a no pointed projections
The last nucleated stage of erythrocytic maturation is orthochromic normoblast or metarubrocyte or nRBC
What percent of hemoglobin is synthesized in the reticulocyte stage? 35%
Epsilon and zeta chains are part of which of the hemaglobins Gower I and II and Portland
Fetal hemaglobin consist of which chains Hgb F (a2y2) alpha and gama
The hemaglobin molecule will either hold onto or release oxygen depending on the venous to pulmonary circulation
The abnormal hemoglobin that will result in a cyanotic condition is hgb m - methemaglobin
How many genes are responsible for the production of alpha chains 4
Which clinical condition is a definitive sign of intravascular lysis hemaglobinemia
Which organs are the most affected during extravascular lysis spleen, lier, lymph nodes and bone marrow
Storage iron is usually determined by the: serum ferritin
In addition to iron ingestion, over 90% of iron in adults is used for erythropoiesis is obtained through recycled of iron from heme
The first stage of iron deficiency anemia is termed continuum of iron depletion of bone marrow
The alpha thalassemic condition that is incompatible with life is barts hydrops fetalis
Which inclusion is associated with a "pitted" golf ball appearance? Hgb H
Failure to thrive, bossed skull, sever anemia, and splenomegaly are all symptoms of beta thalassimia major
one of the gravest clinical problems for individuals with thalassemia major is iron overload
on electrophoresis the majority hemoglobin for individuals with thalassemia major is Hgb F
An appropriate M:E ratio in the case of megaloblastice anemia would be 1:1 - 1:3
What feature is classic in the megalobastic anemias? macrovalocytes
Inffective erythropoiesis is defined as destruction of RBC precursors in the bone marrow prematurly
Spherocytes do not function well in the splenetic environment because osmotic fragility, equilibrium is off
RBC inclusion composed of denatured hemoglobin heinz bodies
Cholelithiasis is frequent complication of patients with hereditary shperocytosis because increase bilirubin, owing to continued hemolysis, causin gall stones
One of the least sever clinical manifestations of G6PD deficency is Congenital nonspherocytic hemolytic anemia
An anemia that manifests as decreased marecellularity,cytopenias in 2 cellular elements and a reticocytopenia is appropriately termed aplastic anemia
the hemoglobin varient that is seen in southeast asian population, shows microcytic picture, and migrates with Hgb c at pH 8.6 hgb E
A patient with sickle cell anemia may develop cardiopulmonary disease due to increased blood viscosity
autosplenectomy is characteristic of sickle cell
When the bone marrow temp ceases to produce cells in a sickle cell patient an aplastic sickle cell crisis has occured
Sickle cell disease is best differentiated from sickle cell trait by Electropheris
Which 'poikilocyte' is classically associated with hemoglobinpathies and liver disease target
What is the most common cause of iron deficiency anemia in adults chronic blood loss
Dysplastic changes of platelets frequently seen in MDS include abnormal granualization and size; magakarocytic fragments and giant platelets
What chromosome disorder in MDS has a poor predictive influence deletion 7
One of the key WBC features in MDS is hypo-hyper granulated cells, pseudo-pelger-huet
Reticulocytopenia is a feature of MDS. What is the mechanism behind this marrow aplasia
The blast count in most individuals with MDS is <20%
The most effective means of treating iron overload in the myelodysplastic syndrome is iron chelation
The morphological classification of anemai in the MDS (myelodysplastic syndrome) is macrocytic, normochromic
Features of Myelodysplastic syndromes macrocytic anemia, cytopenias that affect one or more cell lines, hypercellular bone marrow, organomegaly
The most common hematological malignancy in the adult population is MDS myelodysplastic syndrome
Which new treatment for multiple myeloma was once banned from use for pregnant women thalidomide
Patients with chronic lymphocytic leukemia hypogammaglobinemia, impaired immune function, mono clonal spike
An abnormal proliferation dysfunctional B lymphocyes is commonly associated with CLL and mono
The most characteristic change seen in the peripheral smear of a patient with multiple myeloma rouleaux
A significant feature of hairy cell leukemia not seen in other acute leukemias is pancytopenia
Aperipheral blood picture dominated by cells that appear convoluted with an ovid nucleus and clefting would most likely be seen in sezary syndrome
Hypogammaglobulinemia is a significant feature in half of patients with CLL. This can lead to aha - autoimmune hemolytic anemia
Created by: svankirk