Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
CLLS-300
hemo final
| Question | Answer |
|---|---|
| HCT | 42-52M/37-47W |
| Hgb | 13-18g/dL M/ 11-16 g/dL W |
| MCV | pts hct(L/L)/erythrocyte ct(X10^12/L)= FL 80-96fl |
| MCHC | hgb(gm/dL)/HCT(L/L) = g/dL 32-36% |
| ESR | Erythrocyte Sedimentation Rate 0-15mm/hr 0-20mm/hr |
| retic count | to determine production rate of erythrocytes |
| corrected retic | male 45L/L female 42 L/L |
| fibrinogen | 200-400 mg/dL |
| PT | 12-15.5 sec |
| Thrombin | 15-20 sec |
| aptt | 32-48 sec |
| platelets | 150-400 X 10^9/L |
| MPV | 7.4-10.4fL |
| Bleeding time | vascularity and platelet function in response to injury |
| Clot retraction | see if clot retracts fully within a 24hr period |
| PT | extrinsic & common pathways |
| PT | measures coagulation factors (I,II,VII,X & V) |
| aptt | identify deficiencies in the intrinsic & commom pathways (I,V, IX, X, VIII, XI) |
| Erythropoiesis | production of RBC |
| mature erythrocytes | biconcave, 1/3 central pallor, 120 day life span |
| heme | pigment portion, synthesized as RBC matures, responsible foe transport of oxygen and carbon dioxide |
| vital substances to erythrocyte & hemoglobin production | amino acids, iron, vitamin B12, folic acid, erythropoeitin |
| erythropoietin | produced by kidney, secreted by liver, stimulated by low tissue O2 levels |
| reference range RBC | 4.6-6.2X10^12/L -M 4.2-5.4X10^12/L -F |
| MCH | hgb (X10g/dL)/erythrocyte ct(X10^12/L)=pg |
| anisocytosis | abnormal rbc variation in size/any severe anemia |
| spherocyte | compact rbc, round, lost its central palor/hereditary spherocytosis, Coombs-positive hemolytic anemia |
| stomatocyte | central slit-like opening resembling a mouth/ congenital hemolytic anemia, thalassemia, burns, lupus |
| ovalocyte | oval or egg-like appearance/pernicious anemia |
| poikilocytosis | abnotmal variation in shape/any severe anemia |
| elliptocyte/pencil cell | narrow, elongated, resembling a rod or cigar/various anemia, HbC disease, Thalessemia, Hemolytic anemia |
| codocyte/target cell | rbc with a dark center and periphery and clear ring in between "bull's eye"/ Thalessemia, liver disease, hemoglobinopathies |
| basophillic stippling | multiple uniform dark dots distributed evenly throughout the cell/altered RNA |
| Heinz bodies | small, round inclusions. denatured, precipitated hemoglobin |
| Howell-Jolly Body | DNA: nuclear or chromosomal reminants |
| Pappenheimer Body | clusters of small blue coccoid bodies in periphery of cell, non-heme iron |
| neutrophil | immune defenses, engulf bacteria & cellular debris 40-77% |
| eosinophil | defense against parasites, allergic response 1-4% |
| basophil | inflammatory response, release histamine 0.5-1% |
| monocyte | immune surveillance, engulf cellular debris 2-6% |
| B-lymphocyte | antibody production |
| T-lymphocyte | cellular immune response |
| leukocyte differential | determine the % of each type of leukocyte present & to assess RBC & platelet morph. Can detect disorders or leukemias |
| increase in band cells | shift to left/infection |
| Myeloperoxidase (MPO) | differs Acute Monocytic (+)& Myelogenous from ALL |
| Sudan Black B (SBB) | differs AML(+)from ALL\ |
| Periodic Acid Schiff | myeloblastic & monoblastic from lymphoblastic (+) |
| TdT | ALL (+) from AML |
| responsible for regulating all of the clotting | Thrombin |
| Stuart factor | X/both pathways |
| Hageman factor | XII/Intrinsic |
| IX | Christmas factor/intrinsic |
| prekallikrein | fletcher factor/intrinsic |
| human cell membrane is composed of | proteins, carbohydrates, lipids |
| Phagocytosis & Pinocytosis are examples | Endocytosis |
| deletion | an alteration in the nuclear DNA resulting from the loss of a section of chromatin |
| Hematopoiesis stops in the liver when | 1-2 wks after birth |
| blood cells that normally display vaculozation of the cytoplasm | monocytes |
| stimulate formation of megakaryoblasts to megakaryocytes | Thrombopoietin |
| stimulates WBC formation | Leukopoietin |
| Interleukins | Cytokine involved in development of T & B lymphocytes |
| Interleukin -3 | works with erythropoietin to stimulate CFU-E formation from BFU-E |
| apoptosis | cell death associated with normal physiology |
| meiosis | process of cell division which results in ova & sperm with 1/2 norm number of chromosomes are produced |
| mesoblastic phase | mesenchyme |
| hepatic phase | liver |
| medullary phase | liver & bone marrow |
| reactive lymphocyte | variant lymphocyte |
| which type of hemoglobin is not considered a variant form | Glycosylated hemoglobin |
| what substance, when combined with iron forms a heme molecule | protoporphyrin |
| cells with longstanding chronic anemias appear | hypochromic, microcytic |
| What's the most common glycolytic enzyme deficiency associated with Pentose Phosphate pathway (aerobic) | G6PD deficiency |
| what is the amino acid substitution found in sickle cell anemia | substitution of valine for glutamic acid in the 6th position of beta chain |
| March anemia is an acquired for of which anemia | Hemolytic |
| Thalassemia is best described as | abnormal rate of globin chain synthesis |
| What manifestation of Alpha thalassemia is caused by 4 inactive genes that result in fetal death | Hydrops fetalis with Hb Bart's |
| Manifestation of Alpha thalassemia is caused by 1 inactive alpha gene | silent carrier state |
| lymphocytes | 10-40% |
| cells that produce antibodies and lymphokines | lymphocytes |
| Average life span of a neutrophil in the peripheral blood | 7-10hours |
| NK cells | antibody dependant and independent cytoxicity |
| Memory cells | antigen sensitization, quick response on re-exposure |
| plasmacytes | production of immunoglobulins (antibodies) |
| neutrophil description | segmented nucleus, granulocyte, blue/pink granules |
| monophil description | mononucleus, lacy blue-gray cytoplasm, vacuoles |
| lymphocytes | mononucleus, dense chromatin, sky blue, scant cytoplasm |
| eosinophil | segmented nucleus, granulocyte, red/orange granules |
| basophil | segmented nucleus, granulocyte, azo granules |
| infectious mononucleosis (cell manifestation) | Atypical lymphocyte |
| Niemann-Pick's disease (cell manifestation) | Pick cell |
| Pelger-Huet anomaly (cell manifestation) | Hyposegmented, neutrophils (pince nez) |
| Pernicious anemia (cell manifestation) | Hypersegmented neutrophils |
| Human ehrlichiosis (cell manifestation) | Morulae |
| severe decrease in the total number of lymphocytes in peripheral blood | lymphopenia |
| Ameboid movement of neutrophils from the peripheral blood into the tissue | Diapedisis |
| Release of substances that attract phagocytic cells as the result of traumatic or microbial damage | Chemotaxis |
| Target cell destruction through extracellullar nonphagocytic mechanism | cytotoxic reaction |
| hemoglobinopathies | inherited gene that affect amino acid residual sequence or production of hemoglobin |
| PT time | 12-14 sec |
| APTT | less than 35 sec |
| bleeding time | 2-8 min |
| thrombin clotting time | less than 20 sec |
| Hemophilia A | Factor VIII deficiency |
| HIT | detection of heparin antibodies |
| Hypercoagulable state | detection of Factor V Leiden |
| Vitamin K deiciency | prolonged PT |
| coumadin/warfarin levels | PT |
| heparin | APTT |
| normal INR range | 2.0-3.0 |
| what 3 components interact to produce hemostasis | vasoconstriction, temp platelet plug, blood coagulation |
Created by:
pamela18
Popular Laboratory Science sets