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Hematology Ch 9-12

autosomal disorder with large lysosomal inclusions, recurring infections, and albinism Chediak-higashi sydrome
Initial appearance of specific granulation in the granulocytic series is predominantly seen in: myelocyte
All of the following are mechanisms by which neutropenia is usually produced by viral infection (not bacterial)
The marginating pool of neutrophil is located vessel endothelium in the bone marrow
The monoclonal marker that is often positive in T-ALL (Acute Lymphoblastic Leukimia) is positive CD7 and CD3
Causes of secondary erythrocytosis Hypertension, arterial hypoxemia, drugs, smoking, alcohol, renal disease, renal lesions, endocrine lesions, hepatic lesions, impaired oxygen delivary
Myocardial infractions, transient ischemic attacks, and deep vein thrombosis are more likely to be complications of (PV) Polycytemia Vera
One of the primary glands in the infant responsible for lymphocyte origination is the thymus
Osponization of neutrophils is defined as Stage 2: Attaching to foreign bodies preparing them to be ingested
Tyrosine kinanse is an important mediator in leukocyte metabolic pathways because it suppresses apoptosis (natural cell death)
The red cell morphology that is associated with MMM (myloproliferative Myeloid Metaplasia teardrop, nRBC
Acute leukemia is characterized by Blasts - myeloblast over > 20%
A patient with AML (Acute Myeloid Leukemia)is likely to have a cytochemical panel that is positive for MPO (myeloperoxidase), SSB (sudan Black B), CAE (chloroacetate esterase), NSE (non specific esterase
Which CD markers are appropriately associated with the meylocyte CD45, CD33, CD13
Which CD marker best represents the earliest progenitor cells CD34 (TdT, HCA-DR)
The accelerated phase of chronic myeloid leukemia is marked by basophil > 20%
A "dry tap" is a characteristic of myeloid fibrosis with myeloid metaplasia due to Inability to obtain a spinal tap sample due to the architecture of the bone marrow is disrupted by fibrotic tissue (reticulin)
Pure erythroid leukemia is defined as most marrow cells > 80% comprising of erythroid precursors, w/out myeloid proliferation
What effect does the Ph chromosome t(9:22) have on the prognosis of patients with chronic myelocytic leukemia better prognosis, lacking Ph 1 median survival is 1 yr
The best corrective action to take for a patient who exhibits platelet satellitism in the peripheral blood smear is to collect in sodium citrate tube
The LAP (cytochemical stain) is helpful in distinguishing CML or CGL (Chronic Myelocyte/Granular Leukemia)from Leukemoid reaction. (LAP enzyme is in the granules of neutrophils)
The t(15:17) (q22:q12) is associated with what leukemia(s): APL (Acute Promyelocitic Leukemia)
A high risk factor for the diagnosis of essential thromocythemia is Increased platelet count (>600), age, previous thrombotic event
A patient who has persistent leukocytosis, Dohle bodies, and an elevated LAP score most likely has Leukemoid reaction
Describe Auer rods Elliptical, spindle like inclusions composed of azurophilic granules that may be present in Myeloblast, monoblast, or promyelocytes in AML
A term describing a periphreal blood finding of leukocytosis with a shift to the left accompanied by occasional nRBC's and platelet abnormalities is Leukoerythroblastosis
A white cell disorder that presents with a low WBC count, thrombocytopenia, and a mulberry like inclusion in the monocytes is (HE) Human Erlichiosis (*He goes round the mulberry bush)
Name all the features of the lymphatic system Blood filtration, fluid balance, antibody generation, lymphoporesis
Define delta check Comparing lab results with patients history of lab results
Created by: svankirk