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hematology Ch 1 to 4
| Question | Answer |
|---|---|
| What is the average M:E (myelocyte:erythrocyte) ratio for normal adult none narrow? | 3:1 to 4:1 |
| the key organs involved in extramedullary hematopoiesis include: | liver and spleen |
| which is the best test to assess the bone marrow's response to anemic stress | reticulocyte count |
| anybody-coated red cells that have their antibodies stripped in the spleen usually reappear in the circulation as: | spherocyte |
| a peripheral blood indicator of ineffective bone marrow is | polychromatophilic macrocytes (reticulocyte) |
| the hormone responsible for signaling red cell development in | epo (erythropoietin) |
| what is the perfect size for bone marrow aspiration and biopsy | iliac crest |
| a Wright-stained smear of a patient with an elevated reticulocyte count should show | large red bluish cells, polychromatophilic macrocytes |
| one of the key of morphological features of the nucleus red cell stage is | baseball round nucleus |
| the red cell protein that is responsible for the deformabillity and flexibility of the red cell is | spectrin and ankyrin |
| increased plasma cholesterol may lead to the development of which of these abnormal red cell morphologies | target cells |
| which of the following RBC pathways is responsible for providing 90% of the cellular ATP for red cell metabolism | embden-meyerhof (EM) pathway |
| the hemoglobin molecule consists of | 4 heme molecules with iron at the Center (2 pairs) 2 pairs of globin chains |
| When hemolysis is produced by intravascular fragmentation of red cells, which red cell morphology will be produced? | schistocytes |
| Reversible sickled cells are described as having a | half moon with no pointed projections |
| What percent of hemoglobin is synthesized in the reticulocyte stage | 35% |
| Epsilon and zeta chains are part of which hemoglobin? | Gowers 1 & 2 and Portland |
| Which abnormal hemoglobin will result in a cyanotic condition? | methemoglobin aka Hgb M |
| The hemoglobin molecule will either hold onto or release oxygen depending on the | venous pulmonary circulation to arterial |
| how many genes are responsible for the production of alpha chains? | 4 |
| Fetal hemoglobin consist of what | Hgb F (A2Y2) 'alpha2 gamma2' |
| Which organs are the most affected during extravascular lysis | spleen, liver, lymphnodes, and bone marrow |
| The degree of effective erythropoietic (production of RBCs) activity in any hematological disorder is most readily assessed by the | increased reticulocyte count |
| The red cell inclusion derived from denatured hemoglobin is | Heinz bodies |
| Polychromatophilic macrocytes in the peripheral smear are defined as | reticulocytes |
| The last nucleated stage of erythrocytic maturation is | orthochromic normoblast aka matarubicocyte aka nucleated RBC |
| What clinical condition is a definitive sign of intravascular lysis | hemoglobinemia |
| What is the most useful corrective action for the microscope when details cannot be visualized in immature cells | Use 100x and open diaphragm |
| Behaviors that are standard precautions are: | wearing PPE and treating every patient as if infected |
| Standards and calibrators differ from control materials because | -standards are solutions that have a known amount of analyte and used to calibrate the instrument -Controls are used to monitor the performance after calibration and mimics patient samples |
| Proper mixing of samples and timely delivery of samples to the laboratory are both examples of what type of lab variable | preanalytical |
| A delta check is a historical reference on samples run in the lab. Once a sample fails a delta check, the most obvious corrective action is to | repeat |
| delta checks, results released, critical results released, specimen checked for clotting, and reflex testing initiated are common examples of what type of lab variable | |
| Error analysis, standard protocols, and turnaround time are all part of the: | QA (quality assurance) |
| The average of a group of delta points is defined as the | mean |
Created by:
svankirk
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