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Epinephrine at Work

How epinephrine/norepinephrine work on cardiac mysoties themselves

STEP 1 Binding of epinephrine/norepinephrine changes shape of beta receptor -> activates G-Protein
STEP 2 G-Protein subunit activates adenylate cyclase
STEP 3 Adenylate cyclase catalyzes conversion of ATP to cAMP
STEP 4 cAMP activates protein kinase A
STEP 5 Protein kinase phosphorylates Calcium channels, influx on calcium in cell, stimulates contraction
STEP 6 protein kinase also phosphorylates calcium channels on sarcoplasmic reticulum. calcium then moves into the cytoplasm and stimulates contraction.
STEP 7 Protein kinase phosphorylates myosin, stimulates contraction
STEP 8 Protein kinase phosphorylates sarcoplasmic Calcium ATPase -> speeds removal of calcium from cytoplasm during relaxtion. decreases over relaxtion time.
Created by: zeenat



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