Save
Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't know (0)
Remaining cards (0)
Know (0)
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Adrenal Gland

Clin Chem Exam 2

QuestionAnswer
What are the 3 layers of the adrenal cortex? zona glomerulosa, zona fasciculata, zona reticularis
Zona glomerulosa is related to what hormone? Mineralocorticoids (aldosterone)
Zona fasciculata is related to what hormone? Cortisol (glucocorticoid)
Zone reticularis is related to what hormone? Androgens
Where are the aromatic amines located? adrenal medulla
Cortisol is highest at what time of day? 8-10am
Synthesis and release of corticosteroids is stimulated by ________ ACTH
_______ plasma cortisol is bound to CBG 90%
Adrenal tumor lab values decreased ACTH, decreased CRF, increased cortisol
Adrenal nodular hyperplasia lab values Massive amounts of cortisol produced
Pituitary Cushings syndrome increased ACTH, increased cortisol, decreased CRF
Aldosterone is synthesized in the ________________ zone glomerulosa
Aldosterone is controlled by the __________ system renin-angiotensin system
Primary Conn's disease (hyperaldosteronism) is due to what? overproduction of adrenal cortex (inc aldosterone, inc Na retention, inc hypertension)
Secondary Conn's disease is caused by CHF, nephrotic syndrome, increased renin production, cirrhosis
In the zone reticularis, hormone synthesis is under the control of ____________ ACTH
common defect in the zona reticularis is __________________ androgenital syndrome (21-hydroxylase deficiency)
Congenital adrenal hyperplasia is due to __________ an inherited defect in the genes of 1 or several steroids.
What is the most common deficiency in congenital adrenal hyperplasia? 21-hydroxylase followed by 11B-hydroxylase
Lab results for congenital adrenal hyperplasia? Decreased cortisol and aldosterone, increased ACTH and androgens
Diagnosis for congenital adrenal hyperplasia? Increased plasma 17-hydroxyprogesterone
Testosterone is metabolized into what? (2) Dihydrotestosterone and androtenedione
What are the 17-ketosteroids? metabolites of androgens secreted by both the testes and the adrenal gland
What method is best to measure 17-KS? Zimmerman reaction at 520nm-------purple compound
The adrenal medulla contains ________________ catecholamines
2 major catecholemines are : epinephrine and norepinephrine which are synthesized from phenylalanine
Catecholamines are ____________ biologically active 100%------------half life of 1min
Catecholamines are rapidly metabolized by ____________ catechol-O methyltransferase and monoamine oxidase
What is the primary metabolite of epinephrine and norepinephrine? VMA
Catecholamines are metabolized to ___________ and ____________ metanephrine and VMA
What is pheochromacytoma? Tumor of the chromatin cells of the adrenal medulla due to increased epinephrine and norepinephrine
How to diagnose pheocytochroma? Elevated plasma catecholamines and increased urinary VMA and metnaephrines
Created by: aenewsom
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards