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Pituitary gland

Clin Chem Exam 2

Endocrine gland defintiion and examples? Secretes hormones directly into bloodstream---adrenal, pancreas, gonads
Exocrine gland definition and examples? Secretes hormones via ducts to outside of the organ---mammary, salivary, lachrymal and sebaceous
LIst polypeptide hormones ACTH, TSH, FSH, Prl
Polypeptide hormone receptors are located where? Membrane bound
List steroid hormones Cortisol, estradiol, testosterone
Where are the steroid hormone receptors located? Within the cell (cytoplasmic and nuclear)
Progesterone receptor is produced in response to ________________. Estradiol-17B action
Aromatic amine examples? T3 and T4
Aromatic amines function as __________________? Hormone activated transcription factors
Thyroid hormone receptors bind ________ in the absence of hormone, usually leading to transcriptional repression. DNA
The hypothalamic-pituitary axis controls what function? Neuroendocrine (appetite, sex drive, body temp)
What are the hypothalamic hormones? (4) CRF, TRF, PIF, GnRH
Anterior lobe pituitary hormones? (6) GH, ACTH, TSH, PRL, LH, FSH
Posterior lobe pituitary hormones? (2) ADH, Oxytocin
Thirst and ADH secretion is stimulated by _____________ Increased blood osmolality
1-2% increase in plasma osmolality causes a _____________ increase in ADH production 4 fold
Increases serum osmolality can indicate (6) dehydration, alcohol intoxication, hyperglycemia, hypercalcemia, uremia, diabetes mellitus
Diabetes insipidus is caused by ____________? Decreased ADH
Anterior pituitary hypo-function Complete or partial loss of pituitary function
Anterior pituitary hypo-function causes (3) 1) lesion in hypothalamus 2)pituitary adenoma: panhypopituitarism 3)postpartum necrosis: sheehan's syndrome
Hyper-pituitary function causes (3) 1)pituitary adenoma 2) loss of hypothalamic factors 3)hypo secretion by target organs
Adrenocorticotropic hormone is responsible for _________ cortisol stimulation
Increased ACTH is similar to what syndrome and why? Cushing's syndrom. Acth stimulates the cortex of the adrenal gland to produce cortisol
Decreased ACTH is similar to what syndrome and why? Addison's disease. ACTH deficiency
What are physical symptoms of Cushing's? Abdominal obesity and buffalo hump
What is a physical symptom of Addison's disease? Hyperpigmentation
What does a normal ACTH stimulation test look like? Plasma cortisol should increase with time
What does a person's ACTH stimulation test look like that has a primary adrenal insufficiency? The plasma cortisol level will not increase
Created by: aenewsom