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Adv. Clinical Chem

Exam 1 - Sensitivity and Specificity/Partial Electrolyte

Clinical Sensitivity True Positive / (True Positive + False Negative) Sensitivity = True Positives / All "real" positives
Clinical Specificity True Negative / (True Negative + False Negative) Specificity = True Negative / All "real" negatives
Predictive Value - Positive Test (txtbook) True Positive / (True Positive + False Positive) PV (+) = True Positive / All positive results
Predicitive Value - Negative Test True Negative / (True Negative + False Negative) PV (=) = True Negative / All negative results
2 Standard Deviations (within 2 SD) 95.5% of all values; most important range
3 Standard Deviations (within 3 SD) 99.9% of all values
1 Standard Deviation (within 1 SD) 68.3 % of all values
Prevalence (True Positive + False Negative) / [(True Positive + False Positive) + (True Negative + False Negative)]
Major Electrolytes Na+, K+, Cl-, CO3- etc
Percent Magnesium Unbound 70%
Percent Ca++ Unbound 45% free/ionized - sensitive to blood pH
Anion Gap Equation AG = ([Na+] +[K+]) - ([Cl-]+ [HCO3-]) *Note: HCO3- = 90% of CO2
Osmolality Equation 1.86 [Na+] + Glucose/18 + BUN/2.8 + 9
Glomerular Filtration Rate Equation (ml/min) [Urine Creatinine (mg/dl) * V (ml/24h) * 1.73]/[Serum Creatinine (mg/dl) * (1440/24) * SA]
Created by: UTHSCSA-CLS