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Adv. Clinical Chem
Exam 1 - Sensitivity and Specificity/Partial Electrolyte
Question | Answer |
---|---|
Clinical Sensitivity | True Positive / (True Positive + False Negative) Sensitivity = True Positives / All "real" positives |
Clinical Specificity | True Negative / (True Negative + False Negative) Specificity = True Negative / All "real" negatives |
Predictive Value - Positive Test (txtbook) | True Positive / (True Positive + False Positive) PV (+) = True Positive / All positive results |
Predicitive Value - Negative Test | True Negative / (True Negative + False Negative) PV (=) = True Negative / All negative results |
2 Standard Deviations (within 2 SD) | 95.5% of all values; most important range |
3 Standard Deviations (within 3 SD) | 99.9% of all values |
1 Standard Deviation (within 1 SD) | 68.3 % of all values |
Prevalence | (True Positive + False Negative) / [(True Positive + False Positive) + (True Negative + False Negative)] |
Major Electrolytes | Na+, K+, Cl-, CO3- etc |
Percent Magnesium Unbound | 70% |
Percent Ca++ Unbound | 45% free/ionized - sensitive to blood pH |
Anion Gap Equation | AG = ([Na+] +[K+]) - ([Cl-]+ [HCO3-]) *Note: HCO3- = 90% of CO2 |
Osmolality Equation | 1.86 [Na+] + Glucose/18 + BUN/2.8 + 9 |
Glomerular Filtration Rate Equation (ml/min) | [Urine Creatinine (mg/dl) * V (ml/24h) * 1.73]/[Serum Creatinine (mg/dl) * (1440/24) * SA] |