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Clinically Sig Yeast

Mod 3 Lec 1

QuestionAnswer
Is yeast an endogenous or exogenous infection? Endogenous, opportunist
Candida spp. can cause Vulvo-vaginitis, thrush, pulmonary infections, eye infections, meningitis, endocaridtis, disseminated infections
Thrush is a sign of _____ and is caused by_____. Immunosuppression,Candida spp
The most common cause of yeast infections is? Candida albicans
Candida albicans macro Creamy
Candida albicans micro Clusters of blastoconidia along pseudohyphae, terminal chlamydoconidia
Candida albicans germ tube test result Positive
Candida albicans is sucrose Positive
Candida stellatoidea is sucrose Negative
The second most common Candida spp. is? Candida tropicalis
Candida tropicalis can cause Vaginitis, intestinal disease, systemic infections, meningitis
Candida tropicalis infections are aggressive and difficult to treat with traditional antifungals
Candida tropicalis macro Creamy, glabrous with mycelial fringe
Candida tropicalis micro Blastoconidia are single or small random clusters along pseudohyphae
Candia parapsilosis is a major cause of what? Nosocomial infections, related to indwelling catheters
Candida parapsilosis micro Creamy, glabrous
Candida parapsilosis macro Relatively short, crooked or curved pseudohyphae
Candida kreusi can cause what? Rarely isolated as a cause of endocarditis and vaginitis.
Candida kreusi micro Creamy, flat colonies
Candida kreusi macro Pseudohyphae and elongated blastoconidia, branch like trees
Candida kefyr can cause what? Endocarditis and UTI, one of the 4 most frequently isolated
Candida kefyr micro Creamy, smooth
Candida kefyr macro "logs in a stream" or "log jam"
Candida guilliermondii can cause what? UTI and endocarditis
Candida guilliermondii macro Creamy, flat, glossy
Candida guilliermondii micro Short pseudohyphae with groups of blastoconidia at constrictions
Torulopsis glabrata is also called Candida glabrata
Torulopsis glabrata is most frequently found as Fungemia, can also cause endocarditis, meningitis, UTI
Torulopsis glabrata macro Creamy, smooth, moist
Torulopsis glabrata micro Blastoconidia only (on CMT), no pseudohyphae
The "working yeast" is? Saccharomyces cerevisiae
Saccharomyces cerevisiae is increasingly being isolated from? Immunocompromised
Saccharomyces cerevisiae macro Creamy, smooth, moist
Saccharomyces cerevisiae micro Yeast cells and pseudohyphae
Cryptococcus spp. is the causative agent of? Meningitis and pulmonary disease
Cryptococcus neoformans is found where? Soil contaminated with pigeon droppings
Cryptococcus neoformans is a major cause of what? Opportunistic infections in AIDS patients, also meningitis-predilection for CNS
What do all species of Cryptococcus spp. have? And what is used to detect this? Capsule, India Ink (negative stain)
What does Cryptococcus spp. look like on cornmeal agar? Doesn't produce true or pseudohyphae, blastoconidia only
What are the urease and nitrate results of Cryptococcus spp? Ureast positive in all, nitrate variable
What has a dark colony color on caffeic acid agar or bird seed agar? C. neoformans, melanin production
Rhodotorula spp is closely related to what? Cryptococcus, has a capsule
Rhodotorula spp urease and nitrate results Urease positive, some are nitrate positive
Rhodotorula spp. macro Bright, salmon colored colonies
Geotrichum candidum is normal flora where? Intestinal tract
Geotrichum candidum macro White, moist, yeastlike
Geotrichum candidim micro True hyphae, segments into arthroconidia, no blastoconidia
Trichosporon beigelii causes what? White piedra, emerging agent of disseminated infection mainly in cancer patients.
Trichosporon is resistant to what? Amphotericin B
Trichosporon beigelii micro Produces arthroconidia and blastoconidia on cornmeal agar
Malassezia furfur causes what? Tinea versicolor and catheter related infections in patients on long term IV lipids.
Malassezia furfur macro Cream, brown, wrinkled
Malassezia furfur micro Yeastlike cells with collarettes
Sporobolomyces spp. is mostly recovered from where? Environmental samples
Sporobolomyces spp. macro Salmon colored smooth colonies
Sporobolomyces spp. micro Oval, elongate yeast cells, projectile spores
Pneumocystis jiroveci is the new name for what? Pneumocystis carinii
What is undecided about Pneumocystis jiroveci? Group, is it a yeast, protozoa, fungus
Pneumocystis jiroveci causes what kinds of infections? Opportunistic in AIDS patients, no cellular immunity
What does Pneumocystis pneumonia do? Destroys alveolar cells
How can you diagnose Pneumocystis jiroveci in the lab? Demonstrate organism in tissue, lavage, or sputum
Can Pneumocystis jiroveci be cultured? Only in animals
What is a commonly used stain for Pneumocystis jiroveci? GMS, looks like a "deflated ball"
Created by: blackicecreamcat