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Control of GFR

Control of Glomerular Filtration Rate

What are 2 determinants of GFR? MAP, AFFERENT Arteriole diameter
How would increased Sympathetic activity affect GFR? Increase Sympathetic --> Vasoconstriction --> DECREASE GFR --> decrease Urine Output
How would decreased Symapathetic activity affect GFR? decrease Sympathetic --> Vasodilation --> INCREASE GFR --> increase Urine Output
What effect would Hemorage have on GFR and why? decrease Pressure --> decrease GFR --> conserve H2O and restore Blood volume
How do Epinephrine and Renin affect GFR? Vasoconstricting agents - constrict --> DECREASE GFR
Where does Epinephrine come from? Adrenal Medulla
Where does Renin come from? secreted by the cells of the Juxtaglomerular Complex
What effect do vasodilating agents have on GFR? give an example. dilate --> ^ GFR --> ^ UO
What 3 factors influence Afferent Arteriole diameter? relative Sympathetic activity, Vasoconstricting agents, Vasodilating agents
How does age affect GFR? DECREASE GFR - because of Atherosclerosis
How are BP and GFR correlated? ^ BP --> ^ GFR and decrease BP --> decrease GFR
How is GFR measured? Liters filtered per day - average 93 mm Hg
Where does MAP affect GFR? Global - from the whole body
Where doe Afferent Arteriole diameter affect GFR? Local = best - affect GFR moment to moment
Created by: Kristel