hemostatic disorders Word Scramble
|
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Question | Answer |
Clinical effects of Factor XII deficiency | none |
Describe the clinical bleeding associated with von Willebrand's disease | mucosal bleeding(epistaxis, menorrhagia, GI bleed), excessive bruising, or bleeding after minor trauma |
Describe the clinical bleeding associated with platelet disorders | mucosal bleeding(epistaxis, menorrhagia, GI bleed), excessive bruising, or bleeding after minor trauma |
Describe the bleeding associated with hemophilia | Bleeding into joints, muscles or soft tissues |
The most common causes of primary fibrinolysis | Severe liver disease and hepatic surgery |
In non-bleeding patients with thrombocytopenia caused by marrow failure, prophylactic platelet transfusions are generally reserved for platelet counts less than this number | 10K |
This syndrome is due to deficiency of GPIb/IX in platelets | Bernard-Soulier |
This syndrome is due to deficiency of GPIIb/IIIa in platelets | Glanzmann thrombasthenaa |
This drug has been effective treating bleeding associated with uremia | DDAVP(desmopressin) |
Describe the underlying pathophysiology of the most common type of von Willebrand's disease | Type 1 vWD has mild to moderate quantitative deficiency of vWF |
In this type of von Willebrand's disease, vWF is virtually absent along with Factor VIII | Type 3 vWD |
These lysine analogues are used as anti-fibrinolytics | epsilon aminocaproic acid and tranexamic acid |
Mechanism of action of tranexamic acid and epsilon aminocaproic acid | interfere with plasmin binding to fibrin, thereby inhibiting fibrinolysis (anti-fibrinolytics) |
This site of bleeding is a contraindicationto tranexamic acid and EACA | upper urinary tract bc obstruction may result from failure of clot lysis |
X-linked congenital bleeding disorder caused by Factor VIII deficiency | Hemophilia A |
Products of choice in Hemophilia A | Recombinant Factor VIII |
FDA requires that each unit of cryoprecipitated AHF contain this much factor VIII | 80 IU |
DDAVP and cryo can be useful in the treatment of: A. Hemophilia A B. Hemophilia B C. Both D. Neither | A. |
What is the mainstay of therapy for hemophilia patients with inhibitors to factor VIII or IX? | activated Prothrombin complex concentrates (aPCC) or recombinant Factor VIIa (rFVIIa) |
Treatment of choice for Factor V deficiency | plasma |
Treatment for Factor XII deficiency | none |
This deficiency is associated with umbilical stump bleeding | Factor XIII |
Treatment for alpha2-plasmin inhibitor deficiency | epsilon aminocaproic acid (EACA) |
Vitamin K dependent coagulation factors | II,VII,IX, X |
Warfarin-induced skin necrosis is related to the drug's early effect on this | protein C synthesis |
If patient has serious bleeding on warfarin, this product is recommended | 4-factor (II,VII,IX,X) Prothrombin complex concentrate (PCC) |
Calculation for FFP units needed to reverse heparin effect | plasma is not effective in reversing heparin effect |
Drug used to reverse heparin effect | protamine sulfate |
This drug is a synthetic pentasaccharide that strongly binds anti-thrombin and acts as a selective inhibitor to Factor Xa | Fondaparinux |
This drug is an oral targeted thrombin inhibitor | Dabigatran (Pradaxa) |
These drugs are oral targeted Factor Xa inhibitors | Rivaroxaban (Xarelto) and Apixaban (Eliquis) |
These drugs selectively inhibit ADP-induced activation of platelets via irreversible alteration of the platelet P2Y12 receptor | Clopigrodel (Plavix) and Prasugrel (Effient) |
This is a synthetic analogue of vasopressin | DDAVP |
These factors are released from endothelial cells when DDAVP is given | vWF, Factor VIII, and tPA |
These antifibrinolytic drugs are synthetic analogues of lysine | EACA and Tranexamic acid |
Mechanism of action of tranexamic acid | occupies lysine binding sites of plasminogen and plasminogen activators which delays clot resorption |
This is the most important protease inhibitor of activated coagulation factors and is central to the in-vivo effect of heparin | antithrombin |
Condition in infants with homozygous deficiency of protein C or S | purpura fulminans |
When does "warfarin induced skin necrosis occur"? | When patients with protein C or S deficiency are started on warfarin |
This is the specific antibody epitope in anti-phospholipid syndrome | beta-2 glycoprotein I |
Clinical effect of "Lupus anti-coagulant" | thrombosis |
Lab criteria for Lupus anticoagulant | 1. prolonged PTT 2. prolonged Russell viper venom test 3. fails to correct on 1:1 mixing study 4. corrects when excess phospholipid is added |
This is a drug associated ITP disorder characterized by paradoxical thrombosis | HIT: heparin induced thrombocytopenia |
These tests are used to confirm a dx of HIT | antibodies to platelet factor 4/heparin complexes or serotonin release assay |
Platelet dose for a patient with HIT and a platelet count of 19,000 | none. avoid platelet transfusion in this dx |
The majority of adult-onset cases of TTP have a deficiency of this protein | ADAMTS13 |
Outline treatment of TTP if TPE is not readily available | FFP at 40ml/kg until TPE can be arranged |
Etiology of Typical hemolytic uremic syndrome (HUS) | shiga toxin producing E. coli |
Best treatment for atypical HUS | eculizamab, C5 monoclonal antibody, disease results from excessive activation of alternative complement pathway |
Created by:
jfshikle
Popular Laboratory Science sets