Stomatitis Word Scramble
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| Question | Answer |
| What is the cause of feline stomatitis? JVD Spring 2013 | Inappropriate immune response to oral antigenic stimulation initiating cause is usually not identified, varies from case to case, & is likely multifactorial |
| What are clinical signs of feline stomatitis? JVD Spring 2013 | halitosis, poor grooming, difficulty eating, pain when eating/yawning, irritability, weight loss |
| What infectious agents may be involved in feline stomatitis? JVD Spring 2013 | calicivirus*, herpesvirus, FeLV, FIV, Bartonella henselae |
| What potential contributing factors of stomatitis have been investigated? (5) JVD 2013 | infectious agents, FORL, perio dz, food allergies, hypersensitivity to plaque bacteria |
| How many cats w/stomatitis improve after caudal mouth extractions? JVD Spring 2013 | 60-80% |
| What is the primary mechanism of immunosuppression by cyclosporine?? JVD Spring 2013 | Inhibition of calcineurin inhibits gene expression of inflammatory cytokines. Targets T cells B cell activation and differentialtion may also be partially calcineurin dependent |
| What is the positive feed back loop between T cells and IL2? JVD Spring 2013 | Activated T cells secrete IL-2, which drives proliferation and further expansion of T-cells |
| What are 6 immunomodulatory therapies that have been investigated for Feline stomatitis? JVD Spring 2013 | gold salts, bovine lactoferrin, thalidomide, recombinant feline interferon omega (rFeIFN-w), steroids, cyclosporine |
| What effects do glucocorticoids exert on the immune system? JVD Spring 2013 | decrease neutrophil diapedesis, redistribution of lymphocytes to extravasculra compartments, down regulates maturation of antigen-presenting cells |
| What are side effects of cyclosporine in cats? JVD Spring 2013 | Diarrhea, vomiting, lethargy |
| What dog breed has been show to have a familial predisposition to CUPS? What other dog breeds are most commonly affected? JVD Spring 2011 | Maltese Cavalier King Charles, Grayhounds, Labs (scotties) |
| What are the characteristic histologic findings in CUPS lesions? JVD Spring 2011 | lymphocytic infiltration in the lamina propria and epithelium |
| What are 2 ddx when clinical CUPS lesions are seen? JVD Spring 2011 | uremia & auto-immune dz |
| What is the etiological difference between CUPS and auto-immune dz? JVD Spring 2011 | CUPS is the result of an immune response to chronic antigenic stimulation related to bacteria in the dental plaque. Auto-immune dz involves auto-antibodies targeting mucosal basement membrane or basal keratinocyte components |
| What are 2 kinds of pemphigoid auto-immune dz that can present as vesicular blisters? JVD Spring 2011 | Mucous membrane pemphigoid vs Bullous pemphigoid |
| Which infections agent is commonly associated with chronic gingivostomatitis in cats? Berl Munch Teirarztl Woch 2010 | Calicivirus (FIV, FeLV, & Bartonella were also studied and found to be no different between healthy and diseased cats) |
| What 2 kinds of cancer have been diagnosed in dogs which clinically present similar to stomatitis? 2012 J small anim pract | erythema multiforme & T cell lymphoma |
Created by:
lamarron
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