Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password

Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Block 6-purine pyri Test

Enter the letter for the matching Answer
incorrect
1.
What enzyme is inhibited by fluoroucil? What is it's use
incorrect
2.
What provides the Ribose for pyrine and pyrimidine pathways?
incorrect
3.
IF you have an Adenosine deaminase deficiency what condition results? How is it acquired?
incorrect
4.
What are clinical signs of Lesch-Nyhan?
incorrect
5.
Gout can be caused by deficiency in two enzymes we studied. What are they?
incorrect
6.
What is the most important enzyme in purine synthesis (de novo)
incorrect
7.
What drugs can arrest the growth of rapidly growing cells? How?
incorrect
8.
If HGPRT is not expressed what symptoms arise?
incorrect
9.
eating a lot of what contributes to the build up of mononucleotides and what condition?
incorrect
10.
What three amino acids are very important as Nitrogen sources for purines and pyrimidines?
incorrect
11.
The three important enzymes of pyrimidine synthesis are what?
incorrect
12.
What is ADA deficiency defect and symptoms?
incorrect
13.
How does allopurinol react?
incorrect
14.
What drug can be prescribed to help a gout or hyperuracemia patient? Why?
incorrect
15.
What converts dihydrofolate to THF for the methylation reaction of thymydylate synthetase? Inhibited by?
incorrect
16.
What are the starting products acted upon by carbamoyl phophate synthetase-2 to create carbamoyl phosphate?
incorrect
17.
What enzyme of pyrimidine synthesis frees O2 from hydroxyurea to yeild what?
incorrect
18.
What enzyme is needed to start the de novo synthesis of Pyrimidines?
incorrect
19.
Is the salvage pathway more important for purines or pyrimidines?
incorrect
20.
What are three key roles for nucleotides in a living organism?
A.
Glucose-6-P phosphatase = Von Gierke HGPRT
B.
thymidylate synthase takes deoxygenated uridylmonophosphate to dTMP.
C.
DNA & RNA Energy Transfer reactions (ATP, etc) water soluble vitamins all have adenosine nucleotides= NAD, FMN, FAD, CoA
D.
Lots of foods rich in purines, such as asparagus and organ meat leads to gout
E.
aspartate, glutamine, glycine
F.
Allopurinol inhibits xanthine oxidase
G.
Hexose monophosphate pathway (HMP)
H.
"orange sand" or uric acid crystals passed from kidneys
I.
PRPP amidotransferase catalyses the first, rate-limiting reaction
J.
Ribonucleotide Reductase converts hydroxyurea to UDP,
K.
5FU (5-flourouracil) and methotraxate block synthesis of dTMP
L.
autosomal recessive condition that causes SCID - severe combined immunodeficiency
M.
Uses CO2 + Glutamine + ATP
N.
Carbamoyl Phosphate Synthetase-2
O.
CNS deterioration Mental retardation Hyperurcemia and gouty arthritis compulsive self-mutilation pig herding
P.
adenosine deaminase defective, allows adenosine and amp to accumulate: causes Severe Immunodeficiency (SCID)the B and T lymphocyte disfunction
Q.
non-competitive inhibitor of xanthine oxidase
R.
Purines are bicyclic - this means they are more complicated and require more energy to produce.
S.
dihydrofolate which is inhibited by Methotrexate
T.
Ribonucleotide reductase Thymidylate synthetase Dihydrofolate reductase
Type the Answer that corresponds to the displayed Question.
incorrect
21.
What do you add to carbamoyl phosphate to get an intermediate, ortic acid, that will be acted upon by PRPP synthetase?
incorrect
22.
What is the limiting factor in purine or pyrimidine synthesis?
incorrect
23.
What disease has a complusive drive to self-injure?
incorrect
24.
What tissue must rely exculsively on the salvage pathway because de novo is not possible?

edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how
Created by: El Diablo
Popular Biochemistry sets