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digestion, metabolism, reproductive system

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Answer
4 basic processes of digestion   motility, secretion, digestion, absorption  
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motility   movement of material through the GI tract/alimentary canal; aka mechanical digestion  
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secretion   happens throughout digestion when organs secrete different hormones, paracrines, etc.  
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digestion   breaking bonds; enzymatic process that breaks lipids, proteins and carbohydrates into smaller parts  
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absorption   takes place almost completely in the small intestine, where nutrients enter the bloodstream  
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saliva   99.5% water, also contains electrolytes and protein  
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functions of saliva   moistening and lubricating food, antibacterial actions, solvent for tastants, aids speech  
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amount of saliva produced each day   1-2 L, continuous flow of .5 mL/min due to tonic parasympathetic activation  
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simple salivary reflex   chemoreceptors and pressure sensors respond to food; salivary center is located in the medulla  
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conditioned salivary reflex   salivary center is activated by thinking, seeing, smelling and/or hearing food  
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oral cavity function during digestion   secretion (saliva, amylase), motility (moves food to the esophagus for transport to the stomach, intestines)  
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amylase   enzyme that begins carbohydrate digestion - breaks them into disaccharides; improves taste and begins chemical digestion  
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factors that affect gastric emptying   1. duodenal fat, acid, hypertonicity, and distention (usually these are inhibitory) 2. amount of chyme in the stomach  
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vomiting   controlled by vomit center in the medulla; begins with deep inhalation and closure of the glottis; relaxation of stomach and esphagus, contraction of diaphragm and abdominals  
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functions of the stomach during digestion   motility (regulates movement of material into the small intestine), secretion (HCl, gastrin, mucus, pepsinogen, intrinsic factor)  
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gastrin   hormone that stimulates secretion of HCl  
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amount of secretions from the stomach each day   2 L/day  
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stomach - cells that secrete   mucus cells - mucus, chief cells - pepsinogen, parietal cells - HCl and intrinsic factor  
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function of HCl   activates pepsinogen, optimizes pepsin activity; aids in connective tissue breakdown; denatures proteins; kills most microorganisms  
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pH of the stomach   1-2  
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intrinsic factor   binds to B12, required for absorption of B12 in the small intestine  
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pepsinogen   precursor enzyme that becomes actives when exposed to pH of 2.  
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protease   begins breakdown of proteins into smaller peptide chains  
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hormones/neurotransmitters that influence parietal and chief cell activity in the stomach   acetylcholine, gastrin, histamine, somatostatin  
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3 phases of digestion   cephalic (stimulated by food), gastric (stimulated by internal environment of the stomach), intestinal (stimulated by the small intestine)  
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histamine   paracrine that stimulates secretion  
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somatostatin   inhibitory hormone; suppresses, slows down digestive activity  
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absorption in the stomach   alcohol (slow) and aspirin are absorbed, no food is absorbed here  
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pancreatic secretions   exocrine (pancreatic juice) and endocrine (insulin); regulated during the intestinal phase of digestion  
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pancreatic lipase   breaks down lipids, only source is the pancreas  
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acinar cells   produce pancreatic enzymes (proteolytic enzyme, pancreatic amylase, pancreatic lipase)  
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duct cells   produce aqueous alkaline solution (mucus) that is bicarbonate-rich  
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secretin   hormone released by the pancreas in response to acid  
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cholecystokinin (CCK)   released by the pancreas in response to fat  
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3 sources of bicarbonate that will raise the PH of the digestive tract   duodenum, pancreas, liver (bile)  
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liver secretions   bile - bile salts, cholesterol, bilirubin, aqueous alkaline fluid  
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bilirubin   waste product from breakdown of red blood cells; turns feces green and urine yellow  
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bile salts   required for fat digestion; emulsify fats; are "recycled" via enterohepatic circulation; need 15 g after a big meal, usually only 3-4 g of bile salts are out at a time  
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segmentation   occurs during a meal; mixes and slowly propels; controlled by intestinal pacemaker cells  
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migrating motility complex   intestinal housekeeper; weak persistent waves that move what is left in the intestines right along; contractions break down food, increasing surface area (segmantation); prevents backup of microorganisms  
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small intestine secretion   succus entericus, digestive enzymes (enterokinase, disaccharidases, aminopeptidases)  
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succus entericus   aqueous salt/mucus solution that lubricates and protects the small intestine; contains water needed for hydrolytic digestive reactions, does not include enzymes; about 1/5 L /day secreted  
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enterokinase   activates pancreatic trypsin, breaks down peptides into individual amino acids  
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disaccharidases   sucrase, maltase, lactase  
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3 anatomical features that greatly increase surface area of small intestine   folds, villi, microvilli  
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energy dependent Na+ absorption in the small intestine   apical - symport with Cl-, glucose or amino acid; antiport with H; basal - Na/K pump (requires ATP), located in lateral space creates high osmolarity which drives water absorption  
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carbohydrate and protein absorption in the small intestine   apical - occurs via Na+ dependent symport; basal - facilitated diffusion  
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fat digestion and absorption in the small intestine   large triglycerides are emulsified by bile salts; pancreatic lipase hydrolyzes triglycerides into monoglycerides and free fatty acids; form micelles; monoglycerides/fatty acids cross apical membrane; form chylomicrons; exocytosis -> central lacteals  
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micelles   monoglycerides and free fatty acids that combine with bile salts to aid in transport across apical membrane of the small intestine  
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chylomicrons   resynthesized triglycerides coated with lipoproteins for transport across basal membrane via exocytosis  
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central lacteal role in fat digestion   carries fats that are too large for the bloodstream  
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large intestine functions   motility, secretion, digestion, absorption  
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small intestine functions   motility, secretion, digestion, absorption  
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haustra   pouches in the large intestine that contract slowly and nonpropulsively; aid in water and electrolyte absorption  
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mass movement   occur 3-4 times per day, large portions of ascending/transverse colon contract, driving feces 1/3 to 3/4 the length of the colon over several seconds; controlled by the gastrocolic reflex (stimulated when gastrin is released when food enters the stomach)  
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large intestine secretions   entirely protective, alkaline mucus only, no digestive enzymes; lubricates and aids in passage of material  
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large intestine digestion   occurs by 500-1,000 different species of resident bacteria, vitamin K and glucose from cellulose are digested  
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vitamin K   necessary for the liver to produce certain plasma proteins  
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large intestine absorption   active transport of Na+, passive transport of Cl- and water follows osmotically  
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feces   150 g per day; 100 g is water and 50 g is solid; of the solid feces, 1/3 is bacteria, 2/3 is undigestible substances  
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gastrointestinal hormones   gastrin, secretin, CCK, GIP  
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gastrin   released by the stomach when food is present; increases secretion of HCl and pepsinogen; enhances gastric motility, ileal motility, relaxes ileocecal junction, stimulates mass movements  
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secretin   activated by decrease in pH of small intestine; inhibits gastric emptying and secretion; stimulates pancreas and liver to secrete NaHCO3  
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cholecystokinin (CCK)   stimulated by fat presence in small intestine; inhibits gastric motility and secretion; stimulates pancreatic enzyme secretion; activates contraction of the gall bladder, relaxation of sphincter of Oddi  
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sphincter of Oddi   where bile and pancreatic secretions enter the small intestine  
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Gastric Inhibitory Peptide (GIP)   glucose-dependent insulinotrophic peptide; stimulated by the presence of carbs in the small intestine, acts as a feedforward activator of insulin secretion  
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