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Men's Health

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Question
Answer
USPSTF: prostate   insufficient evidence for/vs in men <75; men >75: harms outweigh risks  
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USPSTF: testicular ca   against routine screening in Asx  
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PSA elevations can precede clinical dz by:   5-10 yrs  
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PSA index   PSA density (PSA conc divided by PSA volume); higher may be assoc w/cancer  
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Utility of free PSA   helps distinguish prostate cancer from BPH in DRE-negative pts with borderline-high PSA  
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Most common formula for prostate volume   ellipsoid formula  
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Acid phosphatase used for:   Dx of prostatic ca; monitor tx w/ neoplastic drugs, esp in metastatic dz  
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Acid phosphatase elevated in prostate:   Adenocarcinoma; Manipulation; Inflammation; Hypertrophy  
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Do not order acid phosphatase immediately after:   DRE, TURP, or prostatic massage  
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Acid phosphatase: specimen   0.5ml serum separated & added to 10µl acid phosphatase preservative (pH 5) within 2 hours of collection  
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Cystoscopy: risks   Infection, bleeding, tear/perf, urinary retention, scar tissue, allergy to anesthetic, epididymitis/ orchitis  
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TRUS: utility   not useful as screening test; US alone cannot establish /exclude the dx; used to evaluate elevated PSA (to locate suspicious area for transrectal biopsy)  
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TRUS not accurate in:   determining local tumor extension  
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Prostate bx: eval men with azoospermia to:   rule out ejaculatory duct cysts or seminal vesicular cysts  
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Prostate bx best performed with:   a spring-driven needle core biopsy device (or biopsy gun)  
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Complications of prostate bx   hematuria, rectal bleeding, hematospermia, urosepsis, & perineal pain  
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Testosterone: indications   Hypogonadism (loss of libido, ED, gynecomastia, osteoporosis, infertility); delayed/ precocious puberty; monitor testost replacement tx or antiandrogen tx; eval ambiguous genitalia  
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Hgb   3 g/dL higher in men  
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Uric acid   2 mg/dL higher in men  
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Testicular U/S: utility   Inflam scrotum; epididymitis; hydrocele; absent/ undescended testicle; torsion; abnormal blood vessels; lump or tumor; most scrotal masses  
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If testicular mass, first do:   dx U/S  
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Use _____ to differentiate torsion from epididymitis   Doppler US  
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Male infertility: most common etiologies   varicocele (37%); idiopathic (25%)  
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Male factors contribute what percent to infertility cases?   40%  
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Male infertility analysis: start with:   semen analysis (if abnormal, look for exposure to toxins (environment, workplace, EtOH, drugs, hypogonadism)  
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Semen analysis: specimen   0.5 mL, room temp, no sex 2-3 (2-5?) days prior, macro & micro analysis within 1 hr  
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Semen analysis: normal volume   volume >2 ml  
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Semen analysis: normal appearance:   beige, opalescent  
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Semen analysis: normal liquefaction:   liquefied within 1 hour  
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Semen analysis: normal pH:   7.2-7.8  
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Semen analysis: normal motility:   ≥ 50%, >50% forward progression  
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Semen analysis: normal sperm concentration:   ≥ 20 x 10(6)/ml  
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Semen analysis: normal morphology:   ≥ 50%  
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Low sperm motility may be due to:   antisperm Ab or infection  
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Abnormal sperm morphology: may be due to:   varicocele, infection, exposure history  
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Low semen volume: may be due to:   retrograde ejaculation or androgen insufficiency  
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Elevated LH: causes   Testicular dysfn; primary testicular fail; CNS dysfn; precocious puberty; postviral orchitis  
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Decreased LH: causes   Testicular tumors; secondary testicular fail; hypopituitarism; hypothalamic-pituitary dysfn  
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FSH normal range   1.5-14.0 mIU/mL  
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Elevated FSH causes   primary gonadal failure, testicular agenesis, alcoholism, gonadotropin-secreting pituitary tumors  
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Decreased FSH causes   Anterior pituitary hypofunction, hypothalamic disorders  
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Limitation of FSH levels   Pulsatile secretion throughout day (physiologic variation within reference range)  
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Primary testicular failure: labs   increased LH/FSH, decreased testosterone  
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Secondary testicular failure: labs   decreased LH, FSH, testosterone  
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Steroid tx for:   spontaneous autoimmunity; also genital infection, testicular obstruction, & IVF  
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Sims-Huhner test   During female LH surge, examine cervical mucus 2-8 hrs post coitus to evaluate sperm & quality of mucus  
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Sims-Huhner test provides info about:   number of sperm, progressive motility, morphology & interaction of spermatozoa with the cervical mucus  
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Seminal plasma fructose: to evaluate:   azoospermia with ejaculate < 1 ml  
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Seminal plasma fructose MOA   Fructose is produced in seminal vesicles (energy source); if absent in ejaculate, implies absence or obstruction of ejaculatory ducts  
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Seminal plasma fructose: specimen:   frozen seminal plasma  
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Post-vasectomy testing: check sperm counts:   After 20 ejaculations; 8-12 weeks post-vasectomy  
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Testicular cancer dx studies   US (shows hyperechoic area). AFP & HCG for staging.  
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Bladder cancer dx studies   Cystoscopy (dx & tx). Excision of small lesions. Excretory urography for large mass (eval renal pelvis / ureter). CT A/P  
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