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Neuro Review

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Question
Answer
Impairment in the frontal lobes can result in...   Loss of simple / complex movement Loss of ability to spontaneously interact Loss of flexible thinking / problem solving Perseveration Inability to focus on a task Mood changes Changes in personality / social behavior Inability to speak  
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Impairment in the temporal lobes can result in...   Difficulty recognizing phases (prosopagnosia) Difficulty understanding spoken words Poor selective attention (verbal / visual) Short-term / long-term memory loss Increased aggressive behavior Inability to categorize objects Persistent talking  
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Impairment in the parietal lobes can result in...   Inability to attend to more than one object at a time Problems w/ reading (alexia) Difficulty writing words (agraphia) Word blindness (inability to recognize words) Difficulty w/ math (dyscalculia) Unilateral neglect Impaired perception of touch  
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Impairment in the occipital lobes can result in...   Visual field cuts Difficulty locating objects in the env Difficulty recognizing movement Difficulty recognizing colors Visual illusions Difficulties reading / writing Word blindness  
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Insula   Portion of the cerebral cortex (fifth lobe) Located underneath parietal, temporal & frontal lobes, deep w/in lateral fissure of cerebral cortex Visceral area for sensory / motor function related to speech & language skills  
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Cerebellum   Inferior to occipital lobes & posterior to brainstem Comprised of 2 hemispheres / divided into 3 lobes each White matter connects to other parts of CNS Gray matter analyzes body movements - crucial for balance / coordination + automatic motor skills  
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Cerebral blood flow   Brain receives blood supply from carotid & vertebral basilar arteries  
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Carotid system   Consists of left / right branches Divides into internal / external carotid arteries Internal carotids supply blood to brain & divide into: ACA, MCA, PCA  
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ACA   Anterior cerebral artery Supplies forebrain  
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MCA   Middle cerebral artery Supplies forebrain  
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PCA   Posterior cerebral artery Supplies posterior cortex, midbrain, brainstem  
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Circle of Willis   Located at base of brain Arterial systems join here Allows blood to flow through both brain hemispheres Safety valve if blood to brain is blocked on one side  
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CVA   Cerebral vascular accidents Occurs when there is a lack of blood flow to any area of brain including brainstem 3rd most common cause of death in U.S. - 33% mortality rate Leading cause of disability in U.S. 550k strokes occur annually  
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Ischemic CVA   Comprise 80% of strokes 4 subtypes: 1. large artery atherothrombotic, 2. small artery / lacunar stroke, 3. embolic stroke, 4. dissection stroke  
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Hemorrhagic CVA   Comprise 20% of strokes - 50% mortality rate Identified by location & subtype: 1. intracerebral (inside brain), 2. extracerebral intracranial (outside brain, inside skull) Blood vessel bursts in brain causing blood to enter surrounding tissue  
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Causes of hemorrhagic stroke   Brain herniation, massive edema, cocaine / drugs, aneurisms (majority), leukemia, clotting deficiency, diet pills, brain tumors Occurs more in women 50-60 years old  
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Causes of ischemic stroke   Male gender, age, family history, hypertension, diabetes, prior TIAs, smoking, excessive alcohol, birth control pills, sedentary lifestyle  
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Types of ischemic stroke   Thrombus - collection of fat / blood from diseased artery that narrows it & blocks flow of blood going to brain Embolism - blood clot containing arterial debris that travels to smaller artery & gets stuck thereby block flow of blood to brain  
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CNS   Central Nervous System is comprised of the brain & spinal cord Each segment of the spinal cord has sensory / motor nerves that innervate the skin, organs & muscles of the body Substantial loss of neurons often leads to disability  
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Brain hemispheres   Right / left hemispheres separated by longitudinal fissure comprised of 2 large bundles of axons known as the corpus callosum 2 hemispheres receive sensory info from the contralateral side of the body & effect movement on the opposite side  
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Hemiparesis   Weakness on one side of the body  
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Hemiplegia   Paralysis on one side of the body  
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Damage to brain hemispheres   Can result in paralysis or loss of sensation left side - generally results in right sided damage right side - generally results in left sided damage  
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How does the brain receive its blood supply?   From carotid & vertebral basilar arteries  
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Sensory neurons   sensors that are sensitive to light, sound, touch, temperature, smell & chemical input  
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Motor neurons   actors that receive excitation from other cells giving rise to muscle impulses & secretion of hormones  
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Interneurons   connect one neuron to another & can notify motor neurons to move a part of the body that has detected dangerous sensory info  
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Describe neuron structure   Each neuron has a body (soma), filamental extensions (dendrites) & longer fibers (axons)  
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Describe neuron function   Neurons communicate w/ each other via dendrites & axons Dendrites receive stimuli from other neurons Axons send stimuli to other neurons, glands & muscles Transmission occurs via electromechanical neurotransmitters  
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Describe the neuron synapse   The bulb of the axon makes contact w/ the dendrite at the synapse. This is where the brain does its work to move, breathe, think & feel  
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Describe the chemical event at the synapse   Action potential reaches the tip of the axon (end bulb) & releases a chemical (neurotransmitters) into the synaptic cleft Chemical is diffused across the cleft & interacts w/ a receptor on postsynaptic membrane giving rise to excitation or inhibition  
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What do neurotransmitters stimulate?   Dendritic endings  
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How does the neural impulse occur?   Through a change in electrical current across the cell membrane & nerve fibers  
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What is the function of the autoreceptor?   At the synapse, the autoreceptor acts as a synaptic thermostat & determines if more or less of a neurotransmitter is needed  
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What is the function of the reuptake transmitter?   At the synapse, the reuptake transmitter acts as a revolving door to re-use the neurotransmitter  
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What happens at the synapse?   Neuron releases a combination of neurotransmitters Some neurotransmitters excite & others inhibit transmission to adjacent neurons  
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Describe the function of neurotransmitters   Chemical part of electrochemical conduction Approx 40-50 types Assist in regulation of brain's ability to control speech / language, motivation, pain, stress, cravings, personality, mood, attention, memory, metabolic functions, etc.  
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3 primary substance groups of neurotransmitters   1. amino acids (major neurotransmitters of brain), 2. peptides (special functions in hypothalamus), 3. monoamines (modulating functions in brain)  
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Amino acids   glutamate, GABA, aspartic acid, glycine  
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Peptides   vasopressin, somatostatin, neurotensin  
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Monoamines   epinephrine, norepinephrine, dopamine, serotonin, melatonin, acetylcholine  
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"Feel good" neurotransmitters   endorphins (mood) norepinephrine (excitation, alertness, arousal, motivation, panic) dopamine (cognition, motivation, pleasure, appetite control) acetylcholine (alertness, sleep-wake cycles, memory, growth, sex) phenylethylamine (infatuation)  
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Inhibitory neurotransmitters   enkephalins (restricts pain, reduces cravings / depression) GABA (anti-stress / anxiety / panic / pain, promotes calmness & focus)  
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Hormonal neurotransmitters   serotonin (mood regulation, promotes sleep, improves self-esteem, lessens worry / depression) melatonin (rest / recuperation, anti-aging, body clock regulation) oxytocin (stimulated by dopamine to promote sex & emotional attachment)  
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Weight of human brain   Birth = 350 grams (12 oz) 1 year old = 1,000 grams (2.2 lbs) Adult = 1,200 - 1,400 grams (2.6 - 3.1 lbs)  
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Describe the coverings of the brain   3 layers of tissues known as meninges protect the brain 1. dura mater 2. arachnoid membrane (subarachnoid space contains blood vessels & CSF) 3. pia mater  
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CSF   cerebrospinal fluid is the clear fluid that circulates throughout the brain & spinal cord, cushioning & protecting them from injury Flows from one ventricle to the next then into subarachnoid space  
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Describe the brain ventricles   4 ventricles total: 2 lateral, 3rd ventricle, 4th ventricle Lateral = located in interior hemispheres of forebrain, connect w/ 3rd ventricle at posterior point which connects to 4th ventricle at medulla  
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What do the ventricles contain?   ventricles & the central canal of spinal cord contain CSF - within each ventricle the choroid plexus produces CSF This is fluid-like blood plasma formed by cells in the 4 ventricles  
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Hydrocephalus   occurs when the flow of CSF is obstructed & accumulates in ventricles or subarachnoid space thereby increasing pressure on the brain children - this condition causes bones in head to spread (head becomes large)  
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What is the function of the cerebral cortex?   involved in primary sensory, primary motor & association area functions complex thinking, learning, personality, movement, touch, vision  
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Describe the structure of the cerebellum   also known as cerebellum, largest part of the brain divided into left / right hemispheres composed of gray matter or cell bodies totaling 6+ billion w/ dendritic connections  
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What is the function of association areas in the cerebral cortex?   to connect sensory & motor areas, give humans the ability to integrate & interpret daily events  
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What is the function of sensory areas in the cerebral cortex?   to get input from the environment, including touch, taste, smell, vision, hearing  
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What is the function of motor areas in the cerebral cortex?   to permit movement in response to needs / wants  
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What is the function of gray matter?   to direct sensory or motor stimuli to the interneurons of the CNS for responsiveness via synaptic activation  
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What does gray matter contain?   nerve cell bodies, glial cells, capillaries, axons, dendrites  
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What does white matter consist of?   axons that travel throughout the cortex (internal capsule) refers to color of the myelinated sheaths that wrap each axon consists of lipids or fatty material  
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Multiple sclerosis destroys the   myelin sheath surrounding the axons  
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Left hemisphere   typically best at processing speech & language involved in verbal memory  
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Right hemisphere   typically best at processing paralinguistic information, pragmatics, non-linguistic information that is visual, spatial, musical, emotional  
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The corpus callosum is critical to   transmission of information between left / right hemispheres  
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Lobes of the brain   each hemisphere is comprised of 4 lobes: frontal, temporal, parietal, occipital  
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Frontal lobe   most anterior part of the brain control of movement, planning / initiating, concentration, emotional responses, disinhibition of behaviors, switching sets to adapt to changes conscious awareness expressive language Broca's area (speech production)  
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Temporal lobe   located laterally in the cerebral hemispheres left temp lobe contains Wernicke's area (lang comprehension) balance, comprehension of language, hearing ability, categorization of skills, some visual perception  
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Parietal lobe   located b/w occipital lobe & central sulcus  
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Occipital lobe   posterior part of the brain receives projections from thalamus via optic nerve & sensory info from eyes retina gets visual input from light, shapes, shading  
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Hemianopsia   visual field cut results from damage to visual cortex  
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Scotoma   small blind area can result from small area of damage in left hemisphere  
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What is the function of the brainstem?   connects brain to spinal cord & regulates primary life functions: breathing, respiration, swallowing, blood pressure, eye movements, heart rate, vomiting, salivation, sneezing, coughing, gagging  
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What does the brainstem consist of?   Medulla oblongata, pons, midbrain  
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