Block 6 purine and pyrimidine metabolism
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| show | Lesch-Nyhan
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| show | X-linked caused by a single point mutation
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| show | "orange sand" or uric acid crystals passed from kidneys
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| show | Nitrogen containing base, carbohydrate (ribose or deoxyribose), a phosphate moiety
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| show | De novo synthesis or salvaged pathway
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| show | aspartate, glutamine, glycine
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| What provides the Ribose for pyrine and pyrimidine pathways? | show 🗑
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| Is the salvage pathway more important for purines or pyrimidines? | show 🗑
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| What are three key roles for nucleotides in a living organism? | show 🗑
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| What is the limiting factor in purine or pyrimidine synthesis? | show 🗑
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| What is the common enzymatic feature of both de novo and salvage? | show 🗑
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| What type of molecule is PRPP? | show 🗑
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| What tissue must rely exculsively on the salvage pathway because de novo is not possible? | show 🗑
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| show | HGPRT - hypoxanthine-guanine-phospho-ribosyl-transferase.. Tissues such as brain cannot synthesize purine mononucleotides for RNA synthesis
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| If HGPRT is not expressed what symptoms arise? | show 🗑
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| show | Carbamoyl Phosphate Synthetase-2
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| What are the starting products acted upon by carbamoyl phophate synthetase-2 to create carbamoyl phosphate? | show 🗑
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| What do you add to carbamoyl phosphate to get an intermediate, ortic acid, that will be acted upon by PRPP synthetase? | show 🗑
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| What does PRPP synthase give off? | show 🗑
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| What enzyme of pyrimidine synthesis frees O2 from hydroxyurea to yeild what? | show 🗑
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| What enzyme is inhibited by fluoroucil? What is it's use | show 🗑
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| show | Ribonucleotide reductase
Thymidylate synthetase
Dihydrofolate reductase
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| What reduces NDPs to dNDP for DNA synthesis? What inhibits this enzyme? | show 🗑
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| What methylates dUMP to dTMP, but requires Tetrahydrofolate (THF)? What inhibits it? | show 🗑
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| What converts dihydrofolate to THF for the methylation reaction of thymydylate synthetase? Inhibited by? | show 🗑
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| What drugs can arrest the growth of rapidly growing cells? How? | show 🗑
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| What is the most important enzyme in purine synthesis (de novo) | show 🗑
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| What drug can be prescribed to help a gout or hyperuracemia patient? Why? | show 🗑
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| What drug helps cancer patients by inhibiting PRPP amidotransferase? | show 🗑
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| eating a lot of what contributes to the build up of mononucleotides and what condition? | show 🗑
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| show | autosomal recessive condition that causes SCID - severe combined immunodeficiency
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| show | adenosine deaminase defective, allows adenosine and amp to accumulate: causes Severe Immunodeficiency (SCID)the B and T lymphocyte disfunction
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| Gout can be caused by deficiency in two enzymes we studied. What are they? | show 🗑
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| show | non-competitive inhibitor of xanthine oxidase
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Created by:
El Diablo
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