Hematology Medical Laboratory Science Multiple Choice
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| Spherocytes present in a peripheral blood smear can indicate: a) autoimmune hemolytic anemia b) iron deficiency c) beta thalassemia | a) autoimmune hemolytic anemia
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| How does hemophilia A differ from hemophilia B? a) the symptoms are drastically different b) hemophilia A is Factor VIII deficient and hemophilia B is Factor IX deficient c) hemophilia A is an inherited disorder and hemophilia B is an acquired disorder | b) hemophilia A is Factor VIII deficient and hemophilia B is Factor IX deficient
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| A corrected prolonged PT result after 24 hours of Vit K therapy suggests what? a) liver disease b) Factor X deficiency c) obstructive jaundice d) a, b, and c e) a and c | a) and c) liver disease and obstructive jaundice
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| CD19 and CD20 cell surface antigens both appear on what type of lymphocyte? a) B cell b) T-helper cell c) Cytotoxic T cell d) T-suppressor cell | a) B cell
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| Which is not usually increased in alpha thalassemia? a) iron binding capacity b) iron saturation c) LD d) bilirubin | a) iron binding capacity (due to inadequate amounts of hemoglobin synthesis)
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| What is the composition of Howell-Jolly bodies? a) Iron b) DNA c) RNA d) parasite | b) DNA
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| Which Hgb % matches a PT with sickle cell trait? a) Hgb A=90%, Hgb S=8%, Hgb A2=2% b) Hgb A=60%, Hgb S=38%, Hgb A2=2% c) Hgb A=40%, Hgb S=58%, Hgb A2=2% d) Hgb A=25%, Hgb S=70%, Hgb A2=5% | b) Hgb A=60%, Hgb S=38%, Hgb A2=2%
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| What clinical condition is associated with tear drop cells? a) myelofigrosis b) uremia c) disseminated intravascular coagulation d) abetalipoproteineimia | a) myelofigrosis
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| What clinical condition is associated with burr cells? a) myelofigrosis b) uremia c) disseminated intravascular coagulation d) abetalipoproteineimia | b) uremia
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| What clinical condition is associated with schistocytes cells? a) myelofigrosis b) uremia c) disseminated intravascular coagulation d) abetalipoproteineimia | c) disseminated intravascular coagulation
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| What clinical condition is associated with acanthocytes? a) myelofigrosis b) uremia c) disseminated intravascular coagulation d) abetalipoproteineimia | d) abetalipoproteineimia
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| Initial aPTT is 63 sec. Immediate mixing study is 26 sec. Incubated mixing study is 65 sec. Has aPTT been corrected? More likely a factor deficiency or coagulation inhibitor causing prolonged aPTT? a) yes, factor b) yes, coag c) no, factor d) no, coag | d) no, coag. Initial mix appears to correct but after incubation, aPTT is still prolonged, indicating a weak or slow-acting coag inhibitor may be present.
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| The beta hemoglobin chain loci are found on which chromosome? a) chromosome 11 b) chromosome 16 | a) chromosome 11
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| The alpha and zeta hemoglobin chain loci are found on which chromosome? a) chromosome 11 b) chromosome 16 | b) chromosome 16
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| Acquired hemophilia A may be the result of which condition? a) anti-factor VIII inhibitor b) factor VIII deficiency c) Warfarin therapy d) thrombosis | a) anti-factor VIII inhibitor
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| Inherited hemophilia A may be the result of which condition? a) anti-factor VIII inhibitor b) factor VIII deficiency c) Warfarin therapy d) thrombosis | b) factor VIII deficiency
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| 76 year old PT with frequent infections and bleeding episodes has peripheral smear showing Auer rods in blast cells. What does this indicate? a) ALL b) AML c) CLL d) liver disease | b) AML acute myeloid leukemia. Auer rods are highly indicative of myeloid blasts
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| Fine basophilic stippling is indicative of which condition? a) infectious mono b) iron deficiency c) leukemia d) hemolytic anemia | d) hemolytic anemia
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| Which test is used to quantify a coagulation inhibitor? a) PT b) thrombin time c) mixing study d) Bethesda assay | d) Bethesda assay
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| Low LAP score, WBC immaturity, and increased WBC is associated with what? a) ALL b) AML c) CLL d) CML | d) CML chronic myelogenous leukemia
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| Which statement best describes a hemoglobinopathy? a) any problem involving Hgb destruction b) any problem associated with Hgb production c) a deletion of the loci of one or more Hgb chains d) a substitution of an amino acid in the Hgb chain | d) a substitution of an amino acid in the Hgb chain
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| Which condition is a genetic platelet disorder characterized by giant platelets, abnormal platelet function and moderate to severe thrombocytopenia? a) Glanzman disorder b) Hemophilia A c) DIC d) Bernard-Soulier syndrome | d) Bernard-Soulier syndrome
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| Heinz bodies and removal of them, producing bite cells are associated with which condition? a) G6PD deficiency b) microangiopathic hemolytic anemia c) abetalipoproteinemia d) beta thalassemia | a) G6PD deficiency
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| Which is not associated with hereditary spherocytosis? a) intravascular hemolysis b) extravascular hemolysis c) increased osmotic fragility d) an MCHC greater than 37% | a) intravascular hemolysis
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| Which organ or tissue do T-lymphocytes mature? a) bone marrow b) lymph nodes c) thymus d) spleen | c) thymus
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| Warfarin inhibits all the following coag factors EXCEPT: a) Factor II b) Factor VII c) Factor IX d) Factor XI | d) Factor XI. Warfarin only inhibits vitamin K dependent factors
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| Codocytes are typically seen in all types of beta thalassemia except: a) major b) minor c) intermedia d) minima | d) minima
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| T or F. Hereditary hemochromatosis is also called an iron overload disorder. | True
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| T or F. Sickle cells along with target cells in a peripheral smear confirms a diagnosis of sickle cell disease. | False. Hgb electrophoresis is necessary to establish underlying condition.
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