Muscle Phisiology
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| show | Skeletal, Cardiac and Smooth.
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| show | Most skeletal muscles are attached to bones of the skeleton enabling them to control body movement. Striated
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| What is the function of Cardiac muscle | show 🗑
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| What is the funtion of Smooth muscle | show 🗑
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| show | A collection of muscle cells, or muscle fibers. Each muscle fiber is a collection of cylindrical cell with serveral 100 nuclei on the surface of the fiber. They are the largest cells in the body, created by the fushion of many embryonic muscle cells.
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| show | 1 MF has a 1000 myfibrils that occupy most intracellular volume, lil space for cytosol & organelles. MyoF made of proteins. Contractile Proteins: Myosin and AnctinRegulatory Proteins: Tropomyosin & troponinGiant Accessory Proteins: Titin & Nebulin
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| show | Created by 250 joined Myosin molecules. A myosin molecule is composed of protein chains that intertwine to form a long tail and pair of tadpole like heads.
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| Thin Filaments | show 🗑
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| show | Excitation: Produce and electrical impulse.Excitation-Contraction coupling: The sequence of action potentials and Calcium felease that initiate contraction.Contraction: Process by which a muscle creates forceRelaxation:
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| -Molecular basis of contraction. | show 🗑
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| show | Myosin heads create crossbridges by tightly binding to G-actin molecules. In this state, no nucleotide (ATP or ADP) occupies the 2nd binding site on the myosin head. In living muscle, the rigor stae occurs for only a very brief period.
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| -2. APT binds and myosin detaches | show 🗑
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| -3. ATP hydrolysis | show 🗑
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| -4.Myosin reattaches: weak binding | show 🗑
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| show | Power stroke begins when Pi released from its myosin binding site. Myosin head swings toward the M line,pushes attached actin filament in same direction. Aka CT b/c myosin head & hinge tilt from 90 angle relative to thick & Thin filaments to a 45 angle.
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| -Release of ADP (Last step) | show 🗑
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| -What is muscle fatigue? | show 🗑
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| show | Muscle fatigue arises from excitation-contraction failure in the MF rather that from failure of control neurons or neuromuscular transmission.
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| Describe the 3 types of skeletal muscle fibers and their characteristics. | show 🗑
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| Slow-Twitch Oxidative; Red muscle, Dark red myoglobin (ST) | show 🗑
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| show | Mid speed of development of max tensionFast Myosin ATPase activityMedium-dShort con't durationHigh Ca2+ATPase act. in SR Mid.MitochFatigue resistant enduranceUse: Standing, walkingGlycotic,but more ox with end.train.metabMed.Cap density
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| show | Speed of dev.of max ten: fastestMyosin ATPase act.: FAstd: LrgCon't dur: ShortCa2+ATPase act SR: High,few mitochEnd: Easy fatigueuse: Lease used: jumpingMetab: Glycol; more anaer than FOGCap den: low
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| show | The basic unit of contraction in an intact skeletal muscle. Composed of a group of muscle fibers that fxn together and the somatice motor newuron that controls them. When the somatic motor neuron fires and action potential, all muscle fibers contract.
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| How do the motor units in fingers and eyes differ from those of larger, more powerful muscles? | show 🗑
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| How is the length of the sarcomeres related to the strength of muscle contraction? | show 🗑
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| What are the other two methods whereby the contraction strength of muscle twitches can be increased? | show 🗑
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| What is meant by treppe? | show 🗑
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| Complete tetanus? | show 🗑
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| Incomplete tetanus? | show 🗑
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| show | Summation of two stimuli that follow one another in time.
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| show | Contractions that create force without moving a load. Muscle has not shortened. sarcomeres shorten, generating force, but elastic elements stretch, allowing muscle length to remain the same.
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| Isotonic muscle contraction. | show 🗑
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