USCSOM: Physiology Muscle
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| Thick filaments are polymers of ______ | myosin
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| Thin filaments are polymers of _______ | actin
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| What blocks the myosin binding site on actin? | tropomyosin
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| What type of troponin binds tropomyosin? | Troponin T
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| What type of troponin inhibits actin/myosin interaction? | Troponin I
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| What type of troponin binds calcium to unblock the myosin binding site? | Troponin C
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| What enzyme transports Ca into the Sarcoplasmic reticulum? | SERCA (Sarcoplasmic endoplasmic reticulum Atp ase)
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| What is EPP? | End Plate Potential
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| What is the equilibrium potential for K? | -90 mV
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| What is the equilibrium potential for Na? | +69 mV
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| What is the equilibrium potential for ACh? | -20 mV
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| What two membrane enzymes are involved with Calcium release in the SR? | ryanodine receptor and DHP (dihydropyridine) receptor
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| What kind of receptors are at the neuro-muscular junction? | nicotinic acetylcholine receptors
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| What disease involves activation of ryanodine receptors by anesthetics? | malignant hyperthermia
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| What is the response to a single action potential? | twitch response
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| What is the term for the maximum response for a muscle fiber? | tetanus
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| What is the term for the force developed for no change in length? | isometric contraction
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| What is the term for a muscle contraction with a constant load? | isotonic contraction
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| What type of muscle fibers are Type I? | slow twitch, slow oxidative
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| What type of mm fibers are Type IIb? | fast, fatigable
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| What type of mm fibers are Type IIa? | fast, fatigue resistant
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| What are dense bodies? | attachment points of actin filaments in smooth muscle
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| What are caveoli? | membrane invaginations of smooth muscle
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| In smooth muscle, Ca binds to what enzyme? | calmodulin
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| Activated calmodulin activates what phosphorylating protein? | MLCK (myosin light chain kinase)
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| What level of phosphorylation is required to produce maximum force? | 30-40%
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