blood donor testing
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| Number one cause of fatal HTR’s | clerical error
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| Type and screen must be repeated every___ hours following a transfusion | 72 hours
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| Type and cross specimens are held for __ days after a transfusion | 7 days
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| The FDA requires type and screen panels to include these antigens | Antigens represented required by FDA: i) D, C, c, E, e, Fya, Fyb, Jka, Jkb, K, k, Lea, Leb, M, N, P1, S, s
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| What is the risk of acute hemolytic reaction? | 1 in 25,000 transfusions
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| What is the risk of HIV-1 infection from a transfusion? | 1 in 1,467,000
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| What is the risk of Hepatitis B infection from a transfusion? | 1 in 282,000-1,000,000 (highest risk of major viruses)
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| What is the risk of Hepatitis C infection from a transfusion? | 1 in 1,149,000
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| What is the risk of HTLV1/2 from a transfusion? | 1 in 4,364,000
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| What is the risk of WNV infection from a transfusion? | remote
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| What is the risk of syphilis from a transfusion? | remote
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| What is the risk of HIV-2 from a transfusion? | remote
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| What is the risk of T. cruzi from a transfusion? | remote
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| What is the risk of bacterial infection from a transfusion? | platelets: 1 in 75000; RBC: 1 in 500,000
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| Genetic material of Hepatitis B virus | DNA virus (Hepadnavirus)
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| Most likely of the major viruses to be transmitted via transfusion | HBV is currently the most likely of the major viruses to be transmitted via transfusion!
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| #1 reason for hepatic transplant in the US | Hepatitis C
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| Genetic material of Hepatitis C virus | RNA
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| Window period for NAT test for HCV | about 7 days
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| Genetic material of HIV | RNA
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| NAT window period for HIV | window period 9-10 days
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| HTLV-I disease associations | HTLV-I disease associations 1) Adult T-cell leukemia/lymphoma (ATLL) 2) HTLV-associated myelopathy (HAM; formerly called “tropical spastic paraparesis”)
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| HTLV-II disease associations | no clear-cut disease associations
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| WNV symptomatic infections result in this length of deferral | Confirmed/suspected WNV infection: 28 days from symptom onset or 14 days after symptoms resolved
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| A donor has a positive NAT test for West Nile Virus. He is asymptomatic. How long should he be deferred from blood donation? | 120 days from test date
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| What is the vector for Chaga's disease? | Transmitted through bite of reduviid bug (“kissing bug”) in Central/South America
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| What are the testing requirements for Chaga's disease for blood donors? | one time per lifetime of donor
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| Strategies to reduce the risk of transfusion transmitted CMV | seronegative donors and leukocyte reduced products
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| Parvovirus B19 causes these diseases | “Fifth disease” in children, red cell aplasia in adults
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| Parvovirus B19 enters RBCs through this antigen | P antigen
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| Are donors tested for babesia? | in northeast and Midwest states; 14 states and D.C.
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