USCSOM: Eicosanoid metabolism
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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What are the 3 main type of eicosanoids? | show 🗑
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What is meant by autocrine factor? | show 🗑
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show | it releases hormones that affects nearby cells
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show | Inflammatory response, smooth muscle contraction
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show | intestine, bronchioles, blood vessels, pregnant uterus
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What is the most common precursor of Eicosanoids? | show 🗑
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What is a PUFA? | show 🗑
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What are the main dietary PUFAs? | show 🗑
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What enzyme initiates eicosanoid production? | show 🗑
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What is the primary FA released by PLA2? | show 🗑
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What pathway from arachidonic acid produce prostaglandins and thromboxins? | show 🗑
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show | trans-C13 and hydroxy-C15
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What molecules lead from PL to thromboxin or prostaglandins? | show 🗑
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What is the role of TXA2? | show 🗑
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What is the role of PGI2? | show 🗑
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show | COX-2
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What inhibits COX-1? | show 🗑
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What drug irreversibly inhibits COX? | show 🗑
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What are effects of COX-1 inhibition toxicity? | show 🗑
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show | inhibits acid secretion in intestinal cells
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What is the role of PGE2? | show 🗑
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show | PLA2: phospholipase A2
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show | COX enzymes
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Arachidonic acid released by PLA2 is eicosanoid by what 3 different ways? | show 🗑
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Draw PGA, PGD, PGE, PGF-alpha, PGG/PGH, PGI | show 🗑
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show | vasodilation (inc. cAMP)
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Functions of PGD2 | show 🗑
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Functions of PGF2 | show 🗑
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How do omega-3 fatty acids work? | show 🗑
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What 2 things are required to inactivate prostaglandins? | show 🗑
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The lipoxygenase pathway occurs in mainly what kind of cell type? | show 🗑
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What is LOX? | show 🗑
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What form of HPETE is the main precursor for most leukotrienes? | show 🗑
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5-HPETE is converted into what in the leukotriene pathway? via what enzyme? | show 🗑
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Hydrolysis of LTA4 yields what product? | show 🗑
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What are the functions of LTB4? | show 🗑
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show | addition of GSH (glutathione)
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What happens from LTC4, to LTD4, to LTE4? | show 🗑
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What are the functions of LTC4 and LTD4? | show 🗑
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What is SRS-A? What molecules make it up? | show 🗑
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show | lipoxin A4, arachidonic acid, 15-lipoxygenase, 5-lipoxygenase, reduction
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show | potent inhibitors of acute inflammation
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show | epoxides, 5,6-EET, 5,6-diHETE
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What is 5,6-EET? | show 🗑
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Created by:
jlellerm
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