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USCSOM: Eicosanoid metabolism

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
What are the 3 main type of eicosanoids?   show
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What is meant by autocrine factor?   show
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show it releases hormones that affects nearby cells  
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show Inflammatory response, smooth muscle contraction  
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show intestine, bronchioles, blood vessels, pregnant uterus  
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What is the most common precursor of Eicosanoids?   show
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What is a PUFA?   show
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What are the main dietary PUFAs?   show
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What enzyme initiates eicosanoid production?   show
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What is the primary FA released by PLA2?   show
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What pathway from arachidonic acid produce prostaglandins and thromboxins?   show
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show trans-C13 and hydroxy-C15  
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What molecules lead from PL to thromboxin or prostaglandins?   show
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What is the role of TXA2?   show
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What is the role of PGI2?   show
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show COX-2  
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What inhibits COX-1?   show
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What drug irreversibly inhibits COX?   show
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What are effects of COX-1 inhibition toxicity?   show
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show inhibits acid secretion in intestinal cells  
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What is the role of PGE2?   show
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show PLA2: phospholipase A2  
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show COX enzymes  
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Arachidonic acid released by PLA2 is eicosanoid by what 3 different ways?   show
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Draw PGA, PGD, PGE, PGF-alpha, PGG/PGH, PGI   show
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show vasodilation (inc. cAMP)  
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Functions of PGD2   show
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Functions of PGF2   show
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How do omega-3 fatty acids work?   show
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What 2 things are required to inactivate prostaglandins?   show
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The lipoxygenase pathway occurs in mainly what kind of cell type?   show
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What is LOX?   show
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What form of HPETE is the main precursor for most leukotrienes?   show
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5-HPETE is converted into what in the leukotriene pathway? via what enzyme?   show
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Hydrolysis of LTA4 yields what product?   show
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What are the functions of LTB4?   show
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show addition of GSH (glutathione)  
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What happens from LTC4, to LTD4, to LTE4?   show
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What are the functions of LTC4 and LTD4?   show
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What is SRS-A? What molecules make it up?   show
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show lipoxin A4, arachidonic acid, 15-lipoxygenase, 5-lipoxygenase, reduction  
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show potent inhibitors of acute inflammation  
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show epoxides, 5,6-EET, 5,6-diHETE  
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What is 5,6-EET?   show
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