WVSOM -- Current and Future Medical uses of Molecular Biology
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| show | using genetic information from genotype and phenoype. Mostly used in psychology.
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| What will a clinician found out by doing a genetic genotype/phenotype test? | show 🗑
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| show | Many types of cancer
Type 2 Diabetes
Alzheimer's disease
Osteoporosis
Infertility
Cardiovascular risk
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| You patient is found to have a highly methylated p53 gene. Do these results suggest that the patient has an increased or decreased risk of developed cancer? | show 🗑
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| What is epigenetics? | show 🗑
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| What are examples of epigenetics? | show 🗑
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| show | Prostrate cancer
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| show | Correct genetic disorders by introducing a normal functioning copy of the defective gene.
No approved/marketed gene tehreapies or RNAi therapies
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| What has to happen for gene therapy to work? | show 🗑
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| show | In vivo and Ex Vivo
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| What is in vivo introduction? | show 🗑
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| show | Cells are removed form a patient and the gene is introduced.
Cells are then transplanted back into the patient.
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| show | We can manipulate viruses in the lab and introduce human genes. Viruses then inject their genetic material into the host cell as part of their life cycle.
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| show | Retroviruses, adenoviruses, adeno-associated viruses and herpes simplex virus 1
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| show | The virus must be engineered to be replication defective. It can infect the cell but not replicate itself
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| What is retroviral vectors | show 🗑
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| What is the risk of retroviral vectors? | show 🗑
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| show | yes, they are string to use them
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| show | viral DNA does not integrate into the hose genome.
DNA is not passed on.
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| What are the problems associated with gene therapy? (6) | show 🗑
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| show | heritable changes in gene expression caused by mechanisms other than changes in DNA sequences
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| What is the current epigenetic test being used for? | show 🗑
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| What are the problems with gene therapy? | show 🗑
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| show | undifferentiated cells with the capacity for self-renewal and the ability to develop into differentiated cells
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| Characteristics of embryonic stem cells | show 🗑
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| show | cells produced by the first gfew divisions of a fertilized egg
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| show | isolated from teh inner cell mass of a blastocyst
can become any cell type except extraembryonic cells
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| What are sources of pluripotent stem cells? | show 🗑
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| What is SCNT | show 🗑
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| show | exposure to the correct environment and growth factors.
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| show | bone marrow transplantation
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| show | patients transplanted with their own stem cells
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| show | patients transplanted with stem cells froma matched donor
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| show | Pluripotent
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| show | manufacturing and product delivery
incredibly expensive
technically difficult so only at a few sites.
Increased risk of cancer
Other unkown risks
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Created by:
tjamrose
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