Cholesterol and Bile Acid Synthesis
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| show | Acetyl CoA
NADPH
ATP
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| HMG-CoA reductase | show 🗑
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| Products of cholesterol synthesis | show 🗑
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| Location of Cholesterol synthesis | show 🗑
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| show | HMG CoA reductase
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| show | decreases
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| HMG CoA is active when | show 🗑
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| show | high
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| show | Glucagon; phosphorylated
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| show | decreasing HMG CoA reductase synthesis
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| show | sterol levels rise
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| Which drug class inhibits this enzyme | show 🗑
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| show | occurs under certain pathological conditions
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| show | regulation
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| show | on lipoprotiens and in cells
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| How does esterification change regulation | show 🗑
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| show | LCAT (Lecithin)
ACAT (acyl CoA)
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| show | Esterifies cholesterol on lipoprotein that can be transferred from HDL to LDL
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| show | esterifies cholesterol within the cell
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| show | under certain pathological conditions
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| Where are cholesterol esterified/de-esterified in cells? | show 🗑
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| Esterifcation of cholesterol | show 🗑
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| show | Lecithin: chelesterol acyl transferase
Esteerifies cholesterol on lipoproteins
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| show | Esterfied cholesterol
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| ACAT | show 🗑
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| show | reveses LCAT and ACAT esterification
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| Bile Salt Synthesis Location | show 🗑
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| show | Cholesterol, ATP, NADPH
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| 4 conjugated bile salts | show 🗑
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| Conjugation of bile salts increases ____________ | show 🗑
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| Solubility enables bile salts to act as | show 🗑
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| Conjugated bile salts composed of | show 🗑
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| How much bile salts are recycled | show 🗑
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| show | .2 - .6
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| Amount of bile salts reabsorbed | show 🗑
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| bile removed by feces | show 🗑
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| Why would we want to decrease bile salt reabsorption | show 🗑
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| Cholesterol esterase | show 🗑
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| show | in feces
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| show | chenocholic acid and chlic acid
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| show | hepatocytes
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| starting compounds of bile acid synthesis | show 🗑
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| show | products and substrate!!!!
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| show | cholic acid and chenocholic acids
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| Conjugated bile salts | show 🗑
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| show | taurocholic
glycocholic
taurochenocholic
glyochenocholic acids
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| show | > 95%
12-32 g/day
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| Why would we want to pharmachologically bind drugs to bile acids | show 🗑
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Created by:
tjamrose
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