WVSOM Class of 2012 Protein Folding, Degradation, and Polymorphism
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| helper proteins that overcome kinetic barriers are called? | heat shock proteins (isomerases)
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| heat shock proteins are also called what? | chaperonins
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| what proteins are involved in folding? | prolyl cis/trans isomerases, protein disulfide isomerases, and disulfide reductases
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| what molecule cleaves peptide bonds in front of aromatic amino acids? | chymotrypsin
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| to degrade proteins, what molecule is added? | ubiquitin
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| what is the ligand that binds to proteins and causes ubiquitin to attach? | E3
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| glycation aggregates are called what? | advanced glycation end products (AGES)
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| HbA1C is a measure of what? | hemoglobin glycosylation
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| what are two major aberrations of protein folding? | prion's disease and alzheimer's disease
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| is an isoform the same or different gene? what about a mutation? | different, same
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| ck is important in regenerating what? | atp
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| what happens to intracellular ck when it is elevated? | it diffuses out of the cell
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| HbF has increased oxygen affinity why? | decreased 2,3-BPG binding
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| HbF gamma chains have what AA instead of serine? | histidine
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| collagens have many ____ which lead to diseases? | polymorphisms
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| what are the 2 human prion diseases? | creutzfeldt-jakob disease and variant cjd
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| protein misfolding can cause the _____ that lead to alzheimer's disease? | plaques
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