USMLE - Goljan, Chapter 3 Immunopathology
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| show | Innate and Acquired
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| show | phagocytes (neutrophils, macrophages), NK cells
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| Name cells of acquired immunity | show 🗑
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| show | Congenital infection because normally, IgM synthesis only begins at birth
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| When does IgG synthesis begin? | show 🗑
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| MHC complex | show 🗑
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| show | bind to CD8 T cells
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| show | bind to CD4 helper T cells
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| show | subset of genes in the MHC region (on chromosome 6)
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| HLA A, B, C | show 🗑
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| HLA DP, DQ, DR | show 🗑
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| HLA-B27 | show 🗑
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| HLA-DR2 | show 🗑
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| HLA-DR3 and DR4 | show 🗑
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| show | secrete IL-2 --> proliferation of CD4/CD8 T cells; secrete gamma-interferon --> activate macrophages; help B cells become antibody-producing plasma cells
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| What do CD8 T cells do? | show 🗑
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| show | CD4 T cells
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| What type of cells do NK cells attack? | show 🗑
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| show | APC's found in skin
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| show | IgE --> activation of mast cells
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| Atopic disorders -- what type of hypersensitivity rxn? | show 🗑
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| Hay fever -- what type of hypersensitivity rxn? | show 🗑
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| show | Type 1
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| Hives -- what type of hypersensitivity rxn? | show 🗑
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| Asthma -- what type of hypersensitivity rxn? | show 🗑
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| anaphylaxis -- what type of hypersensitivity rxn? | show 🗑
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| show | Type 1
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| Mnemonic for Type 1 Hypersensitivity Rxns | show 🗑
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| Mnemonic for Type 2 Hypersensitivity Rxns | show 🗑
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| Name the complement-dependent diseases associated with Type 2 Hypersensitivity reactions | show 🗑
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| show | Complement-independent: DM=Diabetes Mellitus; MG=Myasthenia Gravis; G=Graves; PA=Pernicious Anemia.
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| show | Antibody-dependent
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| show | Type II - antibody dependent, complement-dependent, by lysis (MAC)
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| Hyperacute transplantation rejection -- what type of hypersensitivity rxn? | show 🗑
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| Goodpasteur's Syndrome -- what type of hypersensitivity rxn? | show 🗑
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| Warm IgG autoimmune hemolytic anemia -- what type of hypersensitivity rxn? | show 🗑
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| ABO and Rh disease of the newborn -- what type of hypersensitivity rxns? | show 🗑
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| helminth destruction by eosinophils -- what type of hypersensitivity rxn? | show 🗑
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| show | Immune complex-mediated diseases
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| show | ARTHur was the 3rd PaGaN, RA in SLE with PNEUMONITIS in his PeNis!! ARTH=ArthusRxn; 3rd=Type III; PGN=Post-StrepGlomeruloNephritis; RA=RheumArthritis; SLE; Pneu=HypersensitivityPneumonitis; PN=PolyarteritisNodosum
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| show | Type III - immune complex dependent
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| show | T-cell mediated diseases
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| show | Don't CONTACT Ms. GUILLIAN HASHIMOTO FOR NEURo TrouBles because she's GraVid. D=IDDM; CONTACT=ContactDermatitis; Guillian Barre; HashimotoThyroiditis; Neuritis; TB=tuberculosis; GV=Graft vs. Host Dz
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| show | CD4 T cell mediated; macrophage activation, cytokines released --> inflammation.
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| What is cell-mediated cytolysis Type 4 Hypersensitivity? | show 🗑
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| IL-1 | show 🗑
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| show | Secreted by helper (CD4) T cells --> both helper and cytotoxic T cells --> make more T cells!!
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| show | Secreted by helper (CD4) T cells --> stimulate bone marrow stem cells --> growth and differentiation of progenitors of all blood cells
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| IL-4 | show 🗑
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| IL-5 | show 🗑
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| IL-6 | show 🗑
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| IL-8 | show 🗑
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| IL-10 | show 🗑
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| show | Secreted by B cells to activate NK cells; secreted by macrophages to activate Th1 (IFN-gamma release and phagocytic ingestion of microbes)
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| show | Secreted by Th1 (subset of CD4's) AND NK cells --> stimulate Th1's and macrophages, block Th2
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