USMLE - Goljan, Chapter 3 Immunopathology
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| Name the two types of immunity | show 🗑
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| show | phagocytes (neutrophils, macrophages), NK cells
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| show | B and T cells (antigen-dependent)
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| show | Congenital infection because normally, IgM synthesis only begins at birth
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| When does IgG synthesis begin? | show 🗑
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| show | proteins that display self and non-self antigens to T cells
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| MHC class 1 | show 🗑
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| MHC class 2 | show 🗑
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| show | subset of genes in the MHC region (on chromosome 6)
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| show | Belong to MHC class I group; present on all cells except RBCs; recognized by CD8 T cells and NK cells
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| show | belongs to MHC class II group; present on all antigen-presenting cells (B cells, macrophages, dendritic cells); recognized by CD4 helper T cells
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| HLA-B27 | show 🗑
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| HLA-DR2 | show 🗑
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| show | Type 1 DM
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| Name 3 functions of CD4 T cells | show 🗑
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| show | kill virus-infected, tumor (neoplastic), or foreign cells (donor)
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| show | CD4 T cells
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| show | Virus-infected or tumor (neoplastic)
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| What are dendritic cells? | show 🗑
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| show | IgE --> activation of mast cells
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| show | Type 1
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| Hay fever -- what type of hypersensitivity rxn? | show 🗑
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| show | Type 1
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| Hives -- what type of hypersensitivity rxn? | show 🗑
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| show | Type 1
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| show | Type 1
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| Drug allergy to penicillin -- what type of hypersensitivity rxn? | show 🗑
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| show | ANAPHYLAXIS Annie's ASTHMA FLAREs when her FOOD contains HAY. FLARE = wheal/flare (insect stings, allergy testing); FOOD = food allergies; HAY = hayfever
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| show | The BULLdog E.F. ARF the II HAd GOOD TaPas, while DuM MaG-Gie PAssed on them.
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| show | Complement Dependent: BULL=Bullous pemphigoid; E.F.=Erythroblastosis Fetalis; ARF=Acute Rheumatic Fever; II=type 2; HA=hemolytic anemia; GOOD=Goodpasteur's Syndrome; TP=thrombocytopenic purpura (autoimmune).
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| Name the complement-independent diseases associated with Type 2 Hypersensitivity reactions | show 🗑
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| show | Antibody-dependent
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| show | Type II - antibody dependent, complement-dependent, by lysis (MAC)
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| show | Type II - antibody dependent, complement dependent, by lysis (MAC)
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| show | Type II - antibody dependent, complement dependent, by lysis (MAC)
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| Warm IgG autoimmune hemolytic anemia -- what type of hypersensitivity rxn? | show 🗑
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| ABO and Rh disease of the newborn -- what type of hypersensitivity rxns? | show 🗑
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| show | Type II - antibody dependent, complement INdependent, cell-mediated cytotoxicity
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| show | Immune complex-mediated diseases
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| Mnemonic for Type 3 Hypersensitivity Rxns | show 🗑
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| Serum sickness -- what type of hypersensitivity rxn? | show 🗑
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| Type IV Hypersensitivity Rxns | show 🗑
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| Mnemonic for Type 4 Hypersensitivity Rxns | show 🗑
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| show | CD4 T cell mediated; macrophage activation, cytokines released --> inflammation.
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| show | CD8 T cell cytolysis
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| IL-1 | show 🗑
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| IL-2 | show 🗑
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| IL-3 | show 🗑
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| show | Secreted by Th2 (subset of CD4's) cells 1. B cells --> IgE/IgG production, 2. differentiation of naïve CD4's into Th2's, 3. suppress gamma-interferon actions of macrophages
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| IL-5 | show 🗑
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| show | Secreted by Th2 (subset of CD4's) cells AND macrophages --> acute phase reactants and Ig's by hepatocytes; --> stimulates growth of plasma cells (antibody-producing B cells)
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| IL-8 | show 🗑
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| IL-10 | show 🗑
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| IL-12 | show 🗑
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| IFN-gamma | show 🗑
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