Question | Answer |
What is the cause of feline stomatitis?
JVD Spring 2013 | Inappropriate immune response to oral antigenic stimulation
initiating cause is usually not identified, varies from case to case, & is likely multifactorial |
What are clinical signs of feline stomatitis?
JVD Spring 2013 | halitosis, poor grooming, difficulty eating, pain when eating/yawning, irritability, weight loss |
What infectious agents may be involved in feline stomatitis?
JVD Spring 2013 | calicivirus*, herpesvirus, FeLV, FIV, Bartonella henselae |
What potential contributing factors of stomatitis have been investigated? (5)
JVD 2013 | infectious agents, FORL, perio dz, food allergies, hypersensitivity to plaque bacteria |
How many cats w/stomatitis improve after caudal mouth extractions?
JVD Spring 2013 | 60-80% |
What is the primary mechanism of immunosuppression by cyclosporine??
JVD Spring 2013 | Inhibition of calcineurin inhibits gene expression of inflammatory cytokines. Targets T cells
B cell activation and differentialtion may also be partially calcineurin dependent |
What is the positive feed back loop between T cells and IL2?
JVD Spring 2013 | Activated T cells secrete IL-2, which drives proliferation and further expansion of T-cells |
What are 6 immunomodulatory therapies that have been investigated for Feline stomatitis?
JVD Spring 2013 | gold salts, bovine lactoferrin, thalidomide, recombinant feline interferon omega (rFeIFN-w), steroids, cyclosporine |
What effects do glucocorticoids exert on the immune system?
JVD Spring 2013 | decrease neutrophil diapedesis, redistribution of lymphocytes to extravasculra compartments, down regulates maturation of antigen-presenting cells |
What are side effects of cyclosporine in cats?
JVD Spring 2013 | Diarrhea, vomiting, lethargy |
What dog breed has been show to have a familial predisposition to CUPS? What other dog breeds are most commonly affected?
JVD Spring 2011 | Maltese
Cavalier King Charles, Grayhounds, Labs (scotties) |
What are the characteristic histologic findings in CUPS lesions?
JVD Spring 2011 | lymphocytic infiltration in the lamina propria and epithelium |
What are 2 ddx when clinical CUPS lesions are seen?
JVD Spring 2011 | uremia & auto-immune dz |
What is the etiological difference between CUPS and auto-immune dz?
JVD Spring 2011 | CUPS is the result of an immune response to chronic antigenic stimulation related to bacteria in the dental plaque. Auto-immune dz involves auto-antibodies targeting mucosal basement membrane or basal keratinocyte components |
What are 2 kinds of pemphigoid auto-immune dz that can present as vesicular blisters?
JVD Spring 2011 | Mucous membrane pemphigoid vs Bullous pemphigoid |
Which infections agent is commonly associated with chronic gingivostomatitis in cats?
Berl Munch Teirarztl Woch 2010 | Calicivirus (FIV, FeLV, & Bartonella were also studied and found to be no different between healthy and diseased cats) |
What 2 kinds of cancer have been diagnosed in dogs which clinically present similar to stomatitis?
2012 J small anim pract | erythema multiforme & T cell lymphoma |