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Atherogenesis

QuestionAnswer
First step of atherogenesis Damage to endothelium of blood vessels
Damage to endothelium of blood vessels Deposition of LDL's in intima
Deposition of LDL's in intima Oxidation of LDL's by free radicals
Oxidation of LDL's by free radicals Macrophages phagocytose LDL's via scavenger receptors
Macrophages phagocytose LDL's via scavenger receptors Disregulated uptake of LDL's by macrophages
Disregulated uptake of LDL's by macrophages Macrophage becomes foam cell
Macrophage becomes foam cell Formation of fatty streak and PDGF produced
Formation of fatty streak and PDGF produced Plaque forms and proliferation of smooth muscle cells
Plaque forms and proliferation of smooth muscle cells Migrates to subendothelium
Migrates to subendothelium Fibrous cap forms
Fibrous cap forms Unstable plaque
Unstable plaque Occlusion, preocclusion or rupture
rupture Atheroembolism, Occluding thrombus of thromboembolism
Created by: 511202863
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