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Gene Therapy.

Somatic and Germline Gene Therapy

SomaticGermline
The functioning allele is inserted into the target cell The functioning allele is inserted into the germline cells.
The treatment is short-lived and has to be repeated often. This is because the specialised cells containing the gene do not divide to pass on the allele. All the cells derived from the germline cells will contain a copy of the functioning allele. The offspring may also contain a copy of the functioning allele.
It is more difficult to get the allele into the cell in a functioning state. Genetically modified viruses have been tried but the host becomes immune to them. Liposomes are used but they are not very effective. It is easier to get the allele into the cell but it is banned to engineer human embryo's for ethical reasons.
Any genetic manipulations are restricted to the actual patient. Any genetic manipulations could be passed on to the patients children.
Created by: lucy.
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