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Diabetic Drugs

Insulin and Oral Drugs used in the Tx of DM 1 & II

Onset: 10-15 min Peak: 30-60 min Dur: 5 hrs or less Rapid Acting Insulin (Humalog)(Aspart)(Apidra)
Onset: 30-60 min Peak: 2-4 hrs Dur: 5-7 hrs Short Acting Insulin regular (Humulin R, Novolin R)
Onset: 1-4 hrs Peak: 8-12 hrs Dur: 18-24 NPH (Humulin N, Novolin N) Intermediate Acting
Onset: 6-8 hrs Peak: 12-24 hrs Dur: ??? Detemir (Levemir) Intermediate Acting
Onset: 1-1.5 hrs Peak: NONE Dur: 24 hrs Lantus Long Acting
"Give the Shot while the tray is hot." Rapid Acting (Humalog, Novolog, Apidra)
Used in Insulin Drips Regular (Humulin R, Novolin R)
Associated with U-500 Regular (Humulin R, Novolin R)
Give 30 min before meal once or twice a day NPH (Humulin N, Novolin N)
This is usually mixed with regular insulin NPH (Humulin N, Novolin N)
"Cloudy" NPH (Humulin N, Novolin N)
This cannot be mixed Detemir (Levemir)
This drug does not have a peak Lantus
This drug is usually given at bedtime Lantus
Least risk of Hypoglycemia (Insulin) Lantus
No mixing No IVs Lantus
Hypoglycemia is of greatest risk at these times... Peak drug times During exercise Too much Insulin Skipped meals
Build up off fat cause by lack of rotating injection sites Lipodystrophy
This drug decreases hepatoglycogenesis AND decreases Insulin resistance metformin (Glucophage)
An added benefit on this drug is weight loss metformin (Glucophage)
Only oral antidiabetic that can be used in pregnancy metformin (Glucophage)
Drug of choice for type II diabetics metformin (Glucophage)
IV contrast dye in contraindicated with this drug metformin (Glucophage)
This should be D/C during hospital stay or 48 hrs before and after dx procedures metformin (Glucophage)
IV Contrast Dye + Metformin = Lactic Acidosis
An adverse effect of IV contrast dye related to renal impairment Lactic Acidosis
This drug produces an antabuse effect when mixed with alcohol glipizide (Glucotrol)
Due to the effects on the pancreas, hypoglycemia is a concern for which drugs? Glucotrol (Sulfa) and Prandin (glinide)
Weight gain is an adverse effect in these three oral antidiabetics Glucotrol (Sulfa), Prandin (glinide), and Avandia (glitazone)
This drug is similar to insulin in that it's action is short and fast (meal coverage) Prandin Glinide
This oral antidiabetic should be administered with meals OR Prandially Prandin Glinide
These drugs stimulate release of insulin by acting on the pancreas Glucotrol and Prandin
This drug decreases insulin resistance Avandia "glitazone"
Fluid retention and Edema are adverse rxns to which drug? Avandia "glitazone"
Increase plasma lipid levels are cause by which drug? Avandia "glitazone"
Liver problems are associated with which two oral antidiabetic drugs? Avandia (glitazone) and Precose (Alpha)
This drug is contraindicated in pts with cardiovascular disease Avandia (glitazone)
This drug works in the GI tract by blocking absorption of carbs. Thereby preventing serum glucose spikes Precose (Alpha)
GI effects such as Ab cramping, diarrhea, flatulence, and borborygmus are caused by which drug? Precose (Alpha)
This drug should be taken with the first bite of a meal Precose (Alpha)
Liver toxicity is HUGE with this oral antidiabetic Precose (Alpha)
Amylin synthetic Symlin
This drug delays gastric emptying which suppresses glucagon secretion Symlin
This drug is given SubQ to Type I & II diabetics Symlin
This SubQ antidiabetic should be given with meals Symlin
This drug should be monitored extra carefully for hypoglycemic rxns when taken with insulin Symlin **Especially important with Type I**
Other meds should be taken an hour before these two drugs Symlin and Byetta
Injection site rxns and Nausea are common side effects with these two SubQ antidiabetics Symlin and Byetta
Hormones secreted by intestine after a meal. Incretins
Signal pancreas to increase insulin secretion Incretins
Mimic Incretin hormones Byetta
This drug has a high risk of pancreatitis Byetta
This drug can cause hypoglycemia when mixed with Sulfonylureas (glucotrol) Byetta
This drug is often confused with insulin Byetta
This subQ antidiabetic drug should be administered 30-60 minutes preprandial. Byetta
This drug reduces the breakdown of incretins thereby increasing incretin levels Januvia
Adverse rxns of this drug resemble theh common cold Januvia
This incretin mimetic may be combined with Sulfonylureas (Glucotrol) Januvia
This incretin drug requires only once a day dosing Januvia
Created by: Blitzkid22