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BIO 2117 CHAP 14

INNATE IMMUNITY:ESSENTIAL CONCEPTS

QuestionAnswer
MOST COMMON WBC NEUTROPHILS
PHAGOCYTOSIS & RELEASE CHEMICAL TO KILL BACTERIA NEUTROPHILS
DEAD (PUSS) NEUTROPHILS
LEAST COMMON WBC BASOPHILS
GRANULES ARE HISTAMINES. FIGHT ALLERGIES & INFLAMMATION BASOPHILS
PHAGOCYTIC TO PARASITES, WORM,PROTOZOA, FUNGI EOSINOPHILS
TEMPERS RESPONSE TO INFLAMMATION EOSINOPHILS
NEUTROPHILS, BASOPHILS, EOSINOPHILS GRANULOCYTES
NOT TECHNICALLY A WBC/ FORMED AND REMAIN IN TISSUE MAST CELLS
SIMULAR TO BASOPHILS/ALLERGIC REACTIONS MAST CELLS
MONOCYTES, MACROPHAGES, DENDRITE CELLS LYMPHOCYTES AGRANULOCYTES
PHAGOCYTIC IN BLOOD STREAM MONOCYTES
MONOCYTE AFTER LEAVING THE BLOOD STREAM MACROPHAGES
(BIG EATER) INGEST & DESTROY STRATEGIC PARTICIPANTS IN CERTAIN IMMUNE REACTIONS MACROPHAGES
RELATIVE TO MACROPHAGES RESIDE THRU-OUT RES/ PROCESS FORIEGN MATTER & PRESENT TO LYMPHOCYTES DENDRITE CELLS
T-CELLS (THYMUS RELATED IMMUNITY) B-CELLS(HUMORAL IMMUNITY)PRODUCE ANTIBODIES LYMPHOCYTES
FILTERS BLOOD SPLEEN
MACROPHAGES (DESTROYS OLD DAMAGED RBC) RED PULP
LYMPHATIC FOLLICLE (B-CELLS & T-CELLS) WHITE PULP
WBC'S MOVING OUT OF BLOOD VESSELS (1ST NEUTROPHILS THEN MACROPHAGES) DIAPEDESIS
CHEMICALLY ATTRACT/DISPEL WBC'S (TELLS THEM WHERE TO GO OUTSIDE BLOOD VESSEL) CHEMOTAXIS
WBC'S PLATELETS(1%) BUFFY COAT
80% WATER/NUTRIENT WASTE PLASMA
4 WAYS WBC'S ACCESS THE BODY BLOOD/EXTRACELLULAR FLUID/RE SYSTEM/LYMPHATIC SYSTEM
WBC'S GO EVERYWHERE EXCEPT: BLOOD BRAIN BARRIER TESTES/BLOOD BARRIER SURVEILLANCE
WBC'S LOOK @ MARKERS ON SURFACES OF CELLS DETECTION & RECOGNITION
WBC'S DESTROY NON-SELF CELLS DESTRUCTION
SURVEILLANCE,DETECTION & RECOGNITION, DESTRUCTION 2ND & 3RD LINE OF DEFENSE JOBS
SIGNIFIES YOU (SELF CELL) MHC-I MARKER
INNATE- PHYSICAL, CHEMICAL & GENETIC BARRIERS (SKIN, EYES, RESPIRATORY TRACT, DIGESTIVE TRACT, URINE) 1ST LINE OF DEFENSE
DIGESTS AWAY CELL WALL/CAUSES LYSIS (TEARS, SALIVA, MUCOUS SECRETIONS) LYSOZYME
INTERSPECIES (DIFFERENT SPECIES) INTRASPECIES (DIFFERENCES IN SAME SPECIES- SICKLE CELL) GENETIC BARRIERS
2ND MOST COMMON WBC LYMPHOCYTES
REMAIN IN BONE MARROW TO MATURE/HUMORAL IMMUNITY B-LYMPHOCYTES
TRAVEL FROM BONE MARROW TO THYMUS (TO MATURE) CELL-MEDIATED IMMUNITY T-LYMPHOCYTES
EXTRA-CELLULAR FLUID LYMPH
RETICULOENDOTHELIAL SYSTEM RES
PRODUCED IN RESPONSE TO VIRUSES/ NUCLEUS TRANSCRIBE/ TRANSLATE IFN GENE. IFN DIFFUSES LEAVING CELL BINDS TO UNINFECTED CELL INDUCES PROD OF PROTEINS THAT ELIMINATE/BLOCK VIRUS REPLICATION INTERFERON
O2 TRANSPORT ERYTHROCYTES
THROMBOCYTES; BLOOD CLOTTING PLATELETS
MADE BY BACTERIA OR INVADING ORGANISMS EXOGENOUS PYROGENS
MADE FROM YOUR OWN BODY (INCREASES METABOLISM/ WBC'S/ INTERFERE VIRAL REPLICATION/ IMPAIR MICROBIAL NUTRITION) ENDOGENOUS PYROGENS
PROTEINS INVOLVED IN A REACTION CASCADE (ACTIVATION) COMPLEMENT
ACTIVATION COMPLETE - ENHANCE PHAGOCYTOSIS & INFLAMMATION/ MEMBRANE ATTACK COMPLEX COMPLEMENT FIXATION
COATING BACTERIAL CELLS WITH PROTEINS (HANDLEBARS) THAT MAKE PHAGOCYTOSIS EASIER OPSONIZATION
COMPLIMENT #9; LG DONUT SHAPED HOLE THAT CREATES SMALL PORES IN CELL MEMBRANE CAUSING LYSIS MEMBRANE ATTACK COMPLEX
NEUTROPHILS (BACTERIA) & MACROPHAGES (DAMAGED CELLS & BACTERIA) 2 MAJOR PHAGOCYTES
*INCREASE PHAGOCYTE ABILITY TO PERFORM PHAGOCYTOSIS (OPSONIZATION) *ENHANCES INFLAMMATION *FORM MEMBRANE ATTACK COMPLEX BENEFITS FROM COMPLEMENT FIXATION
NON-SPECIFIC RESPONSE TO TISSUE DAMAGE INFLAMMATION
CYTOKINES,CHEMOKINES, & PROSTAGLANDENS (3)CHEMICAL MESSENGERS RELEASED BY DAMAGED CELLS & MAST CELLS
*DILATE ARTERIOLES *CONSTRICT VENOLES (HYPEREMIA) *INCREASE VASCULAR PERMEABILITY ACTIONS OF HISTAMINES
*RUBOR(REDNESS) *CALOR(HEAT) *TUMOR(SWELLING) *DOLOR(PAIN) (4) CARDINAL SIGNS & SYMPTOMS OF INFLAMMATION
PAIN MEDIATORS/ BLOCKED BY ASPRIN PROSTAGLANDINS
PYROGENS- EXOGENOUS(FROM OUTSIDE) ENDOGENOUS(INTERNALLY PRODUCED) FEVER CAUSES
*INTERFERES WITH VIRAL REPLICATION *INCREASES METABOLISM *SEQUESTER IRON IN CELLS FEVER BENEFITS
Created by: 1677303361
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