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genetics 303, exam1
mendel
| Question | Answer |
|---|---|
| mendel's 1st law | law of equal segregation: separation of d and their reassociation upon fertilization |
| mendel's 2nd law | segregation of alleles of 2 diff genes are indep of 1 another |
| allele | diff form of same gene |
| gene | unit of heredity |
| probability equation | # times an event occurs/total # of events... # of indiv with given phenotype/total # of indiv |
| 3 questions mendel answered | 1. what's inherited? alleles of genes 2. how inherited? according to principles of segregation & indep assortment 3. what's role of chance? known thru Mendel's established probabilities |
| complications studying human traits | 1. most traits aff by 1+ gene & can't b analyzd w/simple mendel genetx 2. many single gene traits that can b followd cause rare diseases, than common phenot 3. genetx is not straight fwd |
| doing probability problems for di & trihybrid crosses | treat as monohybrid crosses. Ex: cross AaBb x AABB (male x female) cross Aa x AA and Bb x BB, ea in own punnett sq |
| how is genetics not straight fwd | -no pure breeding humans -long generatn time -no controlld matings -siblings rarely mate to generate F2 |
| recessive traits | 1.appear in progeny of unaff parents 2. freq show up in consanguineous (really close relations) matings 3. all progeny from 2 aff indiv are aff'd (if both parents have, child has) |
| dominant traits | 1.aff indivs appear in every generation 2. 2 aff parents may have unaff progeny (ex parents may be Rr, Rr...child can be rr) |
| autosomal chromosome | any non-sex chromosome |
| if parents don't have recessive disorder cystic fibrosis, and 1st kid unaff, what's probab 2nd kid will b aff? | w/out aff 1st child, we don't know. unaff child is either RR or Rr, so parents can be RR,Rr or RR,RR or Rr,Rr |
| incomplete dominance | 1.phenot of hybrid may be intermed btw homozyg parents 2.mendel's laws still valid at genotypic level in that phenot still reflective of genot |
| sickle-cell anemia | 1.doesn't decr cell's O2-bindg ability..makes cell prone to early death/cling'g 2.a variant of Hemoglobin HbS results in aggregatn of HbS, causing cells to change shape 3.variant: Glu(hydrophilic) replaced by Val (hydrophobic) |