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Biology PP 23

Mutation

QuestionAnswer
*mutation* changes in DNA sequences; change in sequence of nucleotides
recombination change in the positioning of the genetic material
Two ways that cause mutation errors in DNA replication (mispairing of bases by DNA polymerase) and mutagens (agents that damage DNA)
missense genetic mutation - codon for one amino acid is changed to one that codes for another
frameshifts changes the reading frame of genetic message
can radiation cause mutation? yes
how is thymine dimers made? are made when UV light crosslinks adjacent bases
carcinogens agents that cause cancer
p53 check point guard (if cell is damage, p53 says stop to damage cell and go fix your DNA, induce repair enzyme)
Kinds of mutation deletion, duplication, inversion, reciprocal translocation
reciprocal translocation cross over between non-homologs
inversion region on chromosome are switched
Give an example of disorder of chromosomal translocation chronic myelogenous leukemia (CML)
true or false? cancer cells have many translocation mutation?
Are mutation always bad? they are the bases for evolution
Created by: Tiffastic
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