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CCGA lecture 15

Dr White Rickettsias

QuestionAnswer
Rickettsias are extremely small, with a small amount of peptidoglycan for a wall, Obligate intracellular parasites
R. rickettsii & R. typhi cause human infection
R. rickettsii & R. typhi transmitted by arthropods
R. rickettsii & R. typhi enter host cells by stimulating endocytosis, then digest endosome to release bacteria into the cell
R. rickettsii causes Rocky mountain spotted fever(transmitted by ticks)
Rocky Mountain spotted fever is difficult to diagnose and appears 1-2 weeks after tick bite
R. typhi causes Murine typhus(transmitted by fleas)not usually fatal and treated with antibiotics
Chlamydias DO NOT have cell walls
Chlamydias are obligate intracellular parasites and grow and multiply ONLY within the vesicles of host cells
Chlamydias DO NOT have vectors
Chlamydia trachomatis has a limited host range(one infects mice, ALL OTHERS infect humans)
Chlamydia trachomatis enters through scrapes and abrasions
Chlamydia trachomatis is the most commonly reported sexually transmitted disease in the US
Chlamydia trachomatis was reported in >1 million cases in 2008
Chlamydia trachomatis is estimated to have over 3.5 million asymptomatic cases go unreported yearly
Chlamydia trachomatis is called the "Silent Epidemic"
Chlamydia trachomatis disease Lymphogranuloma venereum causes small initial unnoticed lesions that allow buboes to develop if untreated
Nongonococcal urethritis more than 75% of men show symptoms of genital tract infections
Proctitis inflamation of anus and lining of rectum
Trachoma MOST COMMON PREVENTABLE CAUSE OF BLINDNESS(15% of world blindness)2nd most common after cataracts
PID(Pelvic Inflammatory Disease) 50% of women with asymptomatic Chlamydia trachomatis will develop
Created by: tla1957
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