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Toxin/MOA

from Ensley list

QuestionAnswer
Acetaminophen binds glutathion - liver necrosis
Amitraz Alpha-2 adrenergic agonist
Brodifacoum/Warfarin Block synthesis of Vit K clotting factors (2, 7, 9, 10)
Bromethalin myelin edema, uncoupled oxidative phosphorylation in brain
Cholecalciferol Vit D3 - increase Ca and P from gut, bone and kidney to serum
Strichnine blocks glycine
Zinc Phosphide blocks membrane ion transport - CNS and cardiac block
Metaldehyde reduce brain NT, decrease seizure threshold
Ibuprofen Cox inhibitor - GI
TCA inhibit uptake of serotonin and NE
Organophosphates inhibit AChE
SSRI inhibit uptake of serotonin at PRESYNAPTIC membrane
Onions/Garlic propyl disulfide - free radicals, heinz bodies
Grapes/raisins unknown
xylitol stimulates insulin secretion, reactive oxygen species - destroy liver
Chocolate/coffee methylxanthine alkaloids - Cardiac and CNS stimulant
Pyrethrin type 1 - extend action potential, slow NA type 2 - affect GABA
Created by: willettma
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