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Antibiotics
PT.2 antibiotics
| Question | Answer |
|---|---|
| Natural PCNs | all Gram+ (except Listeria) Neisseria (-) Spirochetes (-, anaerobe) |
| AminoPCNs | SEL (+) SHEPS (-) Neisseria (-) |
| Carboxy and Ureido PCNs | SL (+) [nonPCNase] SHEPS PISE K (if ureido) |
| BLase Inhibitors | PCN Spectrum MSSA MSSE |
| 1st Generation Cephs (drugs) | Cefazolin Cefalexin Cefadine Cefdroxil |
| 2nd Generation Cephs "true" (drugs) | Cefuroxime axetil Cefaclor Cefprozil Cefpodoxime proxetine |
| 2nd Generation Cephs "mycins" (drugs) | Cefoxitin Cefotetan Spectrum = Bacterioides (Gram - Anaerobes) |
| 2nd Gen Cephs "True" (spectrum) | SA, S. Pyogenes HEMP + K + N (Gram -) |
| What is Cefuroxime good for? | treating meningitis in kids |
| 3rd Gen Cephs | Ditoren Dinir Buten Taxime Triaxone Tazidime Zoxime |
| 3rd Gen Cephs Spectrum | SA + SP G- Enteric bacilli P. aeruginosa not SPACE not AmpC |
| 4th Gen Ceph Coverage | SA SPACE |
| 4th Gen Cephs | Cefpirone Cefipime |
| 5th Gen Cephs | Ceftaroline MRSA + SPACE |
| Carbapenems | Imi Mero Dori (Gorillacillin)] Erta |
| Carbapenems (spectrum, yes) | G+, Aerobes and Anaerobes ESBLases, SPACE, |
| Carbapenems (spectrum, no) | VRE MRSA/MRSE S. malto E. faecilis |
| Vancomycin | G+ only spectrum MRSA MRSE |
| Lipoglycopeptide | Telavancin fight cSSSI *need renal adjustment 8H = t50 |
| Cyclic lipopeptide | Daptomycin G+ AEROBES ONLY (MRSA, VRE, E. faecilis) |
| Monobactam | Aztreonam |
| Pen G | 30M half life q4-6 IV only |
| Pen V | penetrates the CSF PO only |
| Procaine Pen G | IM only q12-24H |
| Benzathine Pen G | IM only qWeek (15-30 days = concentrations peak) |
| Nafcillin | Hepatic IV (erratic PO) 30M 1-2g q4-6 |
| Oxacillin | Poor PO highly Protein Bound |
| Cloxacillin | 250-500 mg q6 |
| Dicloxacillin | 125-250 mg q6 |
| Ampicillin | 30M half life 1-2g q4-6 ---------=------------ 250-500 mg QID |
| Amoxicillin | PO 250-500 mg QID (like Ampicillin) |
| CSF penetrants | Class I pcns Class II pcns Ticarcillin, Piperacillin Cefazolin Cefuroxime Cefotaxime Ceftriaxone Ceftaroline |
| What drug can cause seizures as an AE? | imipenem |
| Carbenicillin | 5 grams q4H IV |
| Carbenicillin Indanyl | PO (30-40%) 4-8 tabs QD |
| Ticarcillin | IV 3 grams q4H |
| Piperacillin | IV 3 grams q4 4 grams q6 6 grams q8 |
| Cefazolin | IV 1-2 grams q6-8 PO 250-500 mg QID |
| Cephalexin | PO 250-500 mg QID |
| Cephradine | PO 500mg BID PO 1 gram QD |
| Cefuroxime | 1.5H half life IV 0.75-1.5 grams q8 |
| Cefoxitin | 50M half life 1-2 grams q4-6 |
| Cefotetan | 3-4H half life 1-2 grams q4-6 |
| Cefotaxime | Liver + Active metabolite IV 1-2 grams q6-8 |
| Ceftriaxone | Liver IV High protein binding (yet still CSF) 6-8H half life 1-2 grams q12-24 |
| Cefepime | 2.2H half life 1-2grams q8-12 |
| Ceftaroline | 2.7H half life 600mg q12 Hours |
| Meropenem | 1 gram q8 |
| Doripenem | 500mg q8 |
| Ertapenem | 1 gram q24 highly protein bound |
| Vancomycin | 1-2 grams q12 125-250 mg QID PO and IV |
| Telavancin | -renally adjust -cSSSI q8H |
| What hits MRSA, VRE, and E. faecilis | Daptomycin (cyclic lipopeptide) |
| Which drugs are highly protein bound? | oxacillin ceftriaxone ertapenem |
Created by:
tbruc1987
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