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Gluconeogenesis

Important enzymes, substrates and products of gluconeogenesis

EnzymesProductsSubstrates
Pyruvate Carboxylase Pyruvate --> Oxaloacetate ATP + HCO3 ------> ADP + Pi Biotin
Phosphoenolpyruvate Carboxykinase (PEPCK) Oxaloacetate --> Phosphoenolpyruvate (PEP) GTP --> GDP + CO2
Phosphoglycerate Kinase 3-phosphoglycerate --> 1,3 Bisphosphoglycerate ATP --> ADP
Glyceraldehyde 3-phosphate Dehydrogenase 1,3 Bisphosphoglycerate --> Glyceraldehyde 3-phosphate NADH --> NAD+
Triose Phosphate Isomerase Glyceraldehyde 3-phosphate --> Dihydroxyacetone Phosphate (isomerization)
Aldolase Glyceraldehyde 3-phosphate + Dihydroxyacetone Phosphate --> F-1,6-bisP (none)
Fructose 1,6-bisphosphatase F-1,6-bisP --> F-6-P H20 --> Pi
Phosphoglucose Isomerase F-6-P --> G-6-P (isomerization)
Glucose 6-phosphatases G-6-P --> Glucose H20 --> Pi
Created by: ssherwo
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