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Benzodiacepinas

QuestionAnswer
Son más seguras y menos adictivas que los barbitúricos en relación a la muerte
Usados como anestesia favorece la relajación de los músculos
Las benzodiacepinas ¿son inductores de la anestesia? No
Se unen al receptor GABA
Porción del receptor a la que se unen Omega
Receptor en el que se obtiene un efecto ansiolítico o sedante 3
En el receptor 2 se obtiene un efecto miorelajante o anticonvulsivante
Efecto que se obtiene al unirse al receptor 1 hipnótico
Oxacepam y triazolam tienen vida media corta
Los fármacos de vida media media son alprozalam, lorazepam y temazepam
diazepam, clorazepato y fluoracepam tienen una vida media larga
El R1 del anillo de benceno debe ser atractor de electrones
¿debe o no haber otro sustiyente en el anillo de benceno? No
En el anillo diazepina , un grupo S aumenta o disminuye la actividad Disminuye
En el R2 la alquilación aumenta lipofilia y actividad
Sustituyente en R3 que produce una rapida eliminación F
Este anillo no es indispensable benceno sustituyente p
La halogenación en el R3 del anillo benceno sustituyente favorece conformación y lipofilia
Al favorecer conformación y lipofilia que se obtiene una mejor actividad solo
Al metabolizarse forma metabolitos activos
Son ejemplos de metabolitos activos nordazepam oxacepam
Se eliminan por conjugación con el ácido glucorónico
Son las 4 reacciones metabolicas oxidación dimetilación alquilación cojungación
Efecto colateral propios de las benzodiacepinas amnesia anterograda
Provocan un efecto de rebote
Provocan síndrome de abstinencia
Provocan alteración de la percepción
Created by: elei2
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