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Antidiabéticos

QuestionAnswer
Unicas que alteran membrana Sulfonilureas
Clorpropamida y tabutanol son de Primera generación
Los antidiabéticos de segunda generación son glipizida, gliburida, glimepirida
Un sustituyente en el anillo de beneceno aumenta la potencia
Al aumentar este grupo se le da propiedades antibacterianas y toxicidad Amino
Al agregar el grupo metilo se pierde actividad antebacteriana
Disminuye la toxicidad y potencia hipoglucemiante si se agrega un grupo metilo
Al añadir un Cl ¿ que le ocurre a la potencia y a la duración de acción? aumentan
Esta cadena confiere potencia Alifática
Al sustituir la cadena alquílica por este radical disminuye potencia y toxicidad Alicíclico
El derivado biguanida otorga una accion potente
El mecansimo de las sulfonilureas es que se unen al receptor SUR
Células en las que se encuentra el receptor sur Beta pancréaticos
Efectos colaterales característicos de sulfonilureas Prurito e hipoglicemia
Dicumanol,cloramfenicol, fenilbutazona, inhibidores de la monoamino oxidasa; interaccionan con las sulfonilureas reduciendo su metabolismo
Insulina, alcohol, salicilicados, fármacos B adrenérgicos, inhibidores de monoxidass interaccionan produciendo una accion hipoglucemiante
Clorfibato, fenilbutazona, salicilicatos, sulfonamidas desplazan las sulfonilureas de las proteinas plasmaticas
interaccion en la que disminuye la excrecion urinaria de las sulfonilureas y sus metabolitos glihencamida
Created by: elei2
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