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Week 2 - Chapter 2
Drug Action and Handling
| Term | Definition |
|---|---|
| Low Dose Effect Curve | Measuring the response to the dose of the drug |
| Potency | The amount of drug required to produce an effect |
| Efficacy | Related to the maximal effect of a drug regardless of dose |
| Therapeutic Range | Range between the dose causing the minimum effect and the dose causing the minimum adverse effect |
| Therapeutic Index | Number that determines the safety of a drug |
| Efficacy | The maximum intensity of effect or response that can be produced by a drug |
| Renal | Kidney |
| Hepatic | Liver |
| Biotransformation | The body's way of changing a drug so that it can be more easily excreted by the kidneys |
| Tolerance | The need for an increasingly larger dose of the drug to obtain the same effects as the original dose |
| Duration | The length of a drug's effect |
| Half-Life | The amount of time that passes for its concentration to fall to half (50%) of its original blood level |
| Median Effect Dose (ED50) | The dose required to produce a desired clinical effect in 50% of test subjects; a low effective dose is preferred because it means less drug is needed to achieve desired effects |
| Lethal Dose (LD50) | The amount of a substance that causes death in 50% of a test population; a lower LD means the substance is more toxic |