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Nucleotide Metab

Nucleotide Metabolism

QuestionAnswer
The biochemical roles for nucleotides Activated precursors to DNA/RNA Form activated intermediates :UDP-glucose=glycogen ATP-universal currency of energy Adenine=coenzyme component :NAD+,FAD,Co A cAMP=metabolic regulator
Nucleotide Metabolism Synthesized :from scratch=de novo :from pieces=salvage-major pathway Sugar + Base + Phosphate :carry genetic info :chemical energy :precursors to DNA and RNA :structural basis for nucleotides (sugar)
Biosynthesis of purine nucleotides 9 member ringsAdenine and guanineDe novo:assembled on sugar
What are the sources of atoms for purine? 1:aspartate2:8-N^10-Formyl-THF3,9:glutamine4,5,7:glycine6:CO2
What is the intermediate in purine synthesis? 5-phosphoribosyl amine (PRA)
Synthesis of PRPP Ribose from Pentose Phosphate Pathway(unoxidized branch)+ATP(where highest energy bond is broken and used)Transfers 2 phosphate -->AMP
Committed step in purine synthesis Enzyme=amidophosphoribosyl transferase
De Novo assembly of Purine 10 steps synthesisUtilizes carbon carriersBuilds purine "slowly" All synthesis occurs attached to sugarIMP-inosate-nucleotide analog:functions like A,G,C,U,T:not in DNA:blank slate to make GMP or AMP
What is reciprocal substrate regulation? End product dictates intermediate synthesisBranched synthesisRegulation based on product concentrationOne branch regulates other branch
Control of purine biosynthesis Feedback regulationAllosterically regulatedMultiple regulation pointsTight allosteric regulation by final ringsIMP also inhibits pathway at 2 points allostericallyConserves energy
Pyrimidine synthesis Not attached to ribose while synthesizedOrotate ring synthesized firstOrotate ring attached to ribose (PRPP) nextOrotidylate then converted to pyrimidinePyrimidines then used for DNA and RNA
Biosynthesis of pyrimidine nucleotides 6 member ringIntermediate made:N-carbamoylaspartatePRPP + 6 member ring=nucleotideOrotate like IMP3 products:uracil:cytosine (make more of, have two different roles, DNA and RNA:thymine
What are the sources of atoms for pyrimidine? Carbamoyl phosphateAspartate
Created by: hu0ngerz
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