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Humoral & cell media
Question | Answer |
---|---|
Antibody-mediated response/ humoral | special lymphocytes and the production of anitbodies (protein |
Cell mediated response | Production of special lymphocytes |
lymphocytes | |
B cells | antibodies produced & mature in bone marrow mature move to lymphoid tissue can present to helper t cells which stimulate b cell production |
T cells | killer cells/ cell mediated produced in bone marrow, mature in Thymus gland mature move to lymphoid tissue |
dendritic cells | acts as mobile sentinels on the lookout for antigens phagocytose the antigen enter lymph tissue and present to naiv t cells most effective APC |
macrophage | found stationed throughout tissues phagocytose antigens & display activate t cells |
humoral response | proovidees resistance to specific foreign antigens, particularly pathogens als provides dfenc against subsequent exposure |
b cell development | 1 pathogen enters lymph node directly exposing naive B lymphocytes to antigen 2 B lymphocyte bind with antigen forms a group of cells called a clone 3 most clone cells become plasma cells |
b cell development 2 | 4 antibodies secreted & flood bloodstream. antibody/gen complex 5 some clone cells become memory B cells to sped up immune response on subsequent antigen exposure |
memory cells | increase immune reaction following subsequent exposure to antigens memory cells exist and this means plasma cells form quickly to secrete antibodies |
antibody effect | form antigen-antibody complex main effect is agglutination - causes pathogens to clump together - makes phagocytosis easier - limits spread of pathogens |
antibody effect - other/less common | combine with enzymes/toxins to inactivate them or inhibit their reactions dissolve organisms/ cell lysis coat bacteria - easily consume by phagocytes react with soluble substance to make easy consume bind surface virus prevent entering cell/insert dna |
cell mediated immunity | provides resistance to the body by responding to antign in body cells that have been infected by a virus - cancer cells etc similar process to humoral, assist humoral, take time to develop cells still ned to match to an antigen - specific |
t cell develpment | antigen recognisd by T cell t cell divide and become a group - clone most become killer t cell & other - some become memory killer t cell migrate infected area |
helper t cell | b cells can act as APCs to helper t cell. helper t cell releases cytokines that accelerate humoural response |
killer t cell | act on antigen to release substances to destroy it. also attack cancer cell |
helper t cell | assist humoural response secretes a substance that sensitises more lymphocytes secrete a substance that attracts more macrophages secret a substance that enhances macrophage activity |
memory t cell | remain behind to speed up the response time when exposed to an antigen for the second/third tim |
supressor t cell | inhibit the action of B&T cells once antigen has been eliminated |