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Humoral & cell media

QuestionAnswer
Antibody-mediated response/ humoral special lymphocytes and the production of anitbodies (protein
Cell mediated response Production of special lymphocytes
lymphocytes
B cells antibodies produced & mature in bone marrow mature move to lymphoid tissue can present to helper t cells which stimulate b cell production
T cells killer cells/ cell mediated produced in bone marrow, mature in Thymus gland mature move to lymphoid tissue
dendritic cells acts as mobile sentinels on the lookout for antigens phagocytose the antigen enter lymph tissue and present to naiv t cells most effective APC
macrophage found stationed throughout tissues phagocytose antigens & display activate t cells
humoral response proovidees resistance to specific foreign antigens, particularly pathogens als provides dfenc against subsequent exposure
b cell development 1 pathogen enters lymph node directly exposing naive B lymphocytes to antigen 2 B lymphocyte bind with antigen forms a group of cells called a clone 3 most clone cells become plasma cells
b cell development 2 4 antibodies secreted & flood bloodstream. antibody/gen complex 5 some clone cells become memory B cells to sped up immune response on subsequent antigen exposure
memory cells increase immune reaction following subsequent exposure to antigens memory cells exist and this means plasma cells form quickly to secrete antibodies
antibody effect form antigen-antibody complex main effect is agglutination - causes pathogens to clump together - makes phagocytosis easier - limits spread of pathogens
antibody effect - other/less common combine with enzymes/toxins to inactivate them or inhibit their reactions dissolve organisms/ cell lysis coat bacteria - easily consume by phagocytes react with soluble substance to make easy consume bind surface virus prevent entering cell/insert dna
cell mediated immunity provides resistance to the body by responding to antign in body cells that have been infected by a virus - cancer cells etc similar process to humoral, assist humoral, take time to develop cells still ned to match to an antigen - specific
t cell develpment antigen recognisd by T cell t cell divide and become a group - clone most become killer t cell & other - some become memory killer t cell migrate infected area
helper t cell b cells can act as APCs to helper t cell. helper t cell releases cytokines that accelerate humoural response
killer t cell act on antigen to release substances to destroy it. also attack cancer cell
helper t cell assist humoural response secretes a substance that sensitises more lymphocytes secrete a substance that attracts more macrophages secret a substance that enhances macrophage activity
memory t cell remain behind to speed up the response time when exposed to an antigen for the second/third tim
supressor t cell inhibit the action of B&T cells once antigen has been eliminated
Created by: wegonebefine
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