Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Don't know
remaining cards
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

AntiCancer First Aid

WVSOM -- First Aid -- AntiCancer Drugs

What is log kill? fixed percentage that increaes with growth fraction
When do you use a cell-cycle nonspecific drug? Low fixed growth
What drug is used to rescue from MTX? Leucovorin
What is MTX MoA Folic acid analog that inhibits S phase
What is MoA of 5-FU Pyrimidine analog in S phase
What is 5-FU used for? solid tumors and basal cell carcinoma (topically)
How do you rescue 5-FU toxicity? thymidine
MoA 5-MP purine analog in S phase activated by HGPRTase
What is the important interaction with 6-MP? metabolized by xanthine oxidase so increased toxicity with allopurinol
If you want to give 6-MP to a patient on allopurinol what can you give instead? 6-TG
MoA dactinomycin intercalates in DNA
when do you give dactinomycin wilm's tumor, sarcoma, rhabdosarcoma (childhood tumor)
Doxorubicin side effect cardiotoxicity
what is the antidote for doxorubicin dexrazaxane
when do you give doxorubicin? hodgkin's lymphoma
MoA doxorubicin generate free radicals
Bleomycin MoA G2-phase specific by breakign DNA strans with free radicals
when do you use bleomycin? Testicular cancer adn Hodgkin's
what is side effect of bleomycin pulmonary fibrosis
What is major side effect of cyclophosphamide hemorrhagic cystitis prevented by mesna and aggressive hydration
Nitrosourea clinical use brain tumor
What is side effect of vinblastine Blasts Bone marrow
What is side effect of vincristine? neurotoxicity
MoA paclitaxel M phase and hyperstabilizes mitotic spindles so they can't break down
MoA vincristine/blastine? blocks M phase by blocking polymerization of microtubules
What is major side effect of Cisplastin? NAUSEA!!! Nephrotoxicity and acoustic nerve damage
What part of the cell do drugs work on if they act in M-phase? microtubules
MoA of tomoxifen receptor antagonist in breast and bone blocking the binding of estrogen receptor cells
What drug also has same MoA as tomoxifen? raloxifene
When is imatinib used? CML with philadelphia chromosome
trastuzumab clinical uses monoclonal antibody agains HER-2; aka herceptin
Created by: tjamrose