WVSOM -- First Aid -- AntiCancer Drugs
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| What is log kill? | fixed percentage that increaes with growth fraction
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| When do you use a cell-cycle nonspecific drug? | Low fixed growth
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| What drug is used to rescue from MTX? | Leucovorin
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| What is MTX MoA | Folic acid analog that inhibits S phase
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| What is MoA of 5-FU | Pyrimidine analog in S phase
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| What is 5-FU used for? | solid tumors and basal cell carcinoma (topically)
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| How do you rescue 5-FU toxicity? | thymidine
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| MoA 5-MP | purine analog in S phase activated by HGPRTase
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| What is the important interaction with 6-MP? | metabolized by xanthine oxidase so increased toxicity with allopurinol
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| If you want to give 6-MP to a patient on allopurinol what can you give instead? | 6-TG
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| MoA dactinomycin | intercalates in DNA
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| when do you give dactinomycin | wilm's tumor, sarcoma, rhabdosarcoma (childhood tumor)
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| Doxorubicin side effect | cardiotoxicity
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| what is the antidote for doxorubicin | dexrazaxane
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| when do you give doxorubicin? | hodgkin's lymphoma
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| MoA doxorubicin | generate free radicals
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| Bleomycin MoA | G2-phase specific by breakign DNA strans with free radicals
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| when do you use bleomycin? | Testicular cancer adn Hodgkin's
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| what is side effect of bleomycin | pulmonary fibrosis
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| What is major side effect of cyclophosphamide | hemorrhagic cystitis prevented by mesna and aggressive hydration
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| Nitrosourea clinical use | brain tumor
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| What is side effect of vinblastine | Blasts Bone marrow
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| What is side effect of vincristine? | neurotoxicity
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| MoA paclitaxel | M phase and hyperstabilizes mitotic spindles so they can't break down
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| MoA vincristine/blastine? | blocks M phase by blocking polymerization of microtubules
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| What is major side effect of Cisplastin? | NAUSEA!!! Nephrotoxicity and acoustic nerve damage
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| What part of the cell do drugs work on if they act in M-phase? | microtubules
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| MoA of tomoxifen | receptor antagonist in breast and bone blocking the binding of estrogen receptor cells
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| What drug also has same MoA as tomoxifen? | raloxifene
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| When is imatinib used? | CML with philadelphia chromosome
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| trastuzumab clinical uses | monoclonal antibody agains HER-2; aka herceptin
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Created by:
tjamrose
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