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WVSOM -- First Aid Leukemia/Lymphoma

How do you differentiate acute from chronic leukemias? in acute blasts predomiante. Children and elderly in acute.
How do you differentiate a leukemoid reaction from CML? Leukemoid will have incrased leukocyte alkaline phosphatase
When do you see auer bodies? AML
What do you see in AML? a lot of granules and auer rods
What are auer rods? clumped lysosomes
t(15;17) M3 type of AML
t(9;22) Philadelphia chromosome CML
t(8;14) Burkitt's Lymphoma
c-myc Burkitt's lymphoma
bcl-2 activation follicular lymphoma
t(14;18) Follicular Lymphoma
t(15;17) M3 type of AML
responsive to all-trans retinoic acid) M3 type of AML
t(11;22) Ewing's sarcoma
t(11;14) Mantle Cell Lymphoma
< 15yo ALL
median onset~ 60yo AML
30-60 yo CML
> 60 yo CLL
what is there a big risk of in AML? DIC
TRAP hairy cell leukemia
mature B-cell tumor in the elderly. Hairlike projections Hairy cell leukemia
Smudge cells in peripheral blood smear warm antibody autoimmune hemolytic anemia CLL
TdT+ marker ALL
mediastinal mass ALL
peroxidase-positive cytoplasmic inclusions AML
fried egg appearance multiple myeloma
BENSE JONES PROTEINS!!! Multiple myeloma
M spike Multiple myeloma
hyper calcemia renal insufficiency anema multiple myeloma
Starry sky burkitt's lymphoma
what does bcl-2 inhibit? apoptosis
HTLV-1 Adult T cell lymphoma
sezary syndrome mycosis fungoides adults present with cutaneous patches/nodules cutaneous T-cell lymphoma
ABD and pelvis lymphadenopathy diffuse large B-cell lymphoma
t(8;14) with HIV Diffuse large B-cell lymphoma
CD30/15 Reed sternberg cells
Most common hodgkin; collagen banding lacunar cells Nodular sclerosing
Prognosis vs number of reed sternberg cells the more reed sternberg cells the worst prognosis
EBV related hodgkin's lymphoma Lymphocyte rich
Byeloid stem cells "Blast crisis" CML
Lymphocytes Non-antibody-producing B cells CLL
Myeloblasts AML
Lymphoblasts (pre-B or pre-T) ALL
abnormal stem cells in bone marrow leukemia
HTLV 2 hairy Cell Leukemia
increased RBC/WBC/Platelets Polycythemia vera
increased platelets >1million platelets Essential thrombocytosis
tear drop cells with big spleen myelofibrosis
decreased RBC increased WBC/platelets CML
itchying in shower due to abnormal histamine release polycythemia
Created by: tjamrose