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WVSOM FA -- 7
WVSOM -- First Aid Leukemia/Lymphoma
Question | Answer |
---|---|
How do you differentiate acute from chronic leukemias? | in acute blasts predomiante. Children and elderly in acute. |
How do you differentiate a leukemoid reaction from CML? | Leukemoid will have incrased leukocyte alkaline phosphatase |
When do you see auer bodies? | AML |
What do you see in AML? | a lot of granules and auer rods |
What are auer rods? | clumped lysosomes |
M3 | AML |
t(15;17) | M3 type of AML |
t(9;22) | Philadelphia chromosome CML |
t(8;14) | Burkitt's Lymphoma |
c-myc | Burkitt's lymphoma |
bcl-2 activation | follicular lymphoma |
t(14;18) | Follicular Lymphoma |
t(15;17) | M3 type of AML |
responsive to all-trans retinoic acid) | M3 type of AML |
t(11;22) | Ewing's sarcoma |
t(11;14) | Mantle Cell Lymphoma |
< 15yo | ALL |
median onset~ 60yo | AML |
30-60 yo | CML |
> 60 yo | CLL |
what is there a big risk of in AML? | DIC |
TRAP | hairy cell leukemia |
mature B-cell tumor in the elderly. Hairlike projections | Hairy cell leukemia |
Smudge cells in peripheral blood smear warm antibody autoimmune hemolytic anemia | CLL |
CD10 | ALL |
TdT+ marker | ALL |
mediastinal mass | ALL |
peroxidase-positive cytoplasmic inclusions | AML |
fried egg appearance | multiple myeloma |
BENSE JONES PROTEINS!!! | Multiple myeloma |
M spike | Multiple myeloma |
hyper calcemia renal insufficiency anema | multiple myeloma |
Starry sky | burkitt's lymphoma |
what does bcl-2 inhibit? | apoptosis |
HTLV-1 | Adult T cell lymphoma |
sezary syndrome | mycosis fungoides adults present with cutaneous patches/nodules cutaneous T-cell lymphoma |
ABD and pelvis lymphadenopathy | diffuse large B-cell lymphoma |
t(8;14) with HIV | Diffuse large B-cell lymphoma |
CD30/15 | Reed sternberg cells |
Most common hodgkin; collagen banding lacunar cells | Nodular sclerosing |
Prognosis vs number of reed sternberg cells | the more reed sternberg cells the worst prognosis |
EBV related hodgkin's lymphoma | Lymphocyte rich |
Byeloid stem cells "Blast crisis" | CML |
Lymphocytes Non-antibody-producing B cells | CLL |
Myeloblasts | AML |
Lymphoblasts (pre-B or pre-T) | ALL |
abnormal stem cells in bone marrow | leukemia |
HTLV 2 | hairy Cell Leukemia |
increased RBC/WBC/Platelets | Polycythemia vera |
increased platelets >1million platelets | Essential thrombocytosis |
tear drop cells with big spleen | myelofibrosis |
decreased RBC increased WBC/platelets | CML |
itchying in shower due to abnormal histamine release | polycythemia |