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WVSOM FA -- 7
WVSOM -- First Aid Leukemia/Lymphoma
| Question | Answer |
|---|---|
| How do you differentiate acute from chronic leukemias? | in acute blasts predomiante. Children and elderly in acute. |
| How do you differentiate a leukemoid reaction from CML? | Leukemoid will have incrased leukocyte alkaline phosphatase |
| When do you see auer bodies? | AML |
| What do you see in AML? | a lot of granules and auer rods |
| What are auer rods? | clumped lysosomes |
| M3 | AML |
| t(15;17) | M3 type of AML |
| t(9;22) | Philadelphia chromosome CML |
| t(8;14) | Burkitt's Lymphoma |
| c-myc | Burkitt's lymphoma |
| bcl-2 activation | follicular lymphoma |
| t(14;18) | Follicular Lymphoma |
| t(15;17) | M3 type of AML |
| responsive to all-trans retinoic acid) | M3 type of AML |
| t(11;22) | Ewing's sarcoma |
| t(11;14) | Mantle Cell Lymphoma |
| < 15yo | ALL |
| median onset~ 60yo | AML |
| 30-60 yo | CML |
| > 60 yo | CLL |
| what is there a big risk of in AML? | DIC |
| TRAP | hairy cell leukemia |
| mature B-cell tumor in the elderly. Hairlike projections | Hairy cell leukemia |
| Smudge cells in peripheral blood smear warm antibody autoimmune hemolytic anemia | CLL |
| CD10 | ALL |
| TdT+ marker | ALL |
| mediastinal mass | ALL |
| peroxidase-positive cytoplasmic inclusions | AML |
| fried egg appearance | multiple myeloma |
| BENSE JONES PROTEINS!!! | Multiple myeloma |
| M spike | Multiple myeloma |
| hyper calcemia renal insufficiency anema | multiple myeloma |
| Starry sky | burkitt's lymphoma |
| what does bcl-2 inhibit? | apoptosis |
| HTLV-1 | Adult T cell lymphoma |
| sezary syndrome | mycosis fungoides adults present with cutaneous patches/nodules cutaneous T-cell lymphoma |
| ABD and pelvis lymphadenopathy | diffuse large B-cell lymphoma |
| t(8;14) with HIV | Diffuse large B-cell lymphoma |
| CD30/15 | Reed sternberg cells |
| Most common hodgkin; collagen banding lacunar cells | Nodular sclerosing |
| Prognosis vs number of reed sternberg cells | the more reed sternberg cells the worst prognosis |
| EBV related hodgkin's lymphoma | Lymphocyte rich |
| Byeloid stem cells "Blast crisis" | CML |
| Lymphocytes Non-antibody-producing B cells | CLL |
| Myeloblasts | AML |
| Lymphoblasts (pre-B or pre-T) | ALL |
| abnormal stem cells in bone marrow | leukemia |
| HTLV 2 | hairy Cell Leukemia |
| increased RBC/WBC/Platelets | Polycythemia vera |
| increased platelets >1million platelets | Essential thrombocytosis |
| tear drop cells with big spleen | myelofibrosis |
| decreased RBC increased WBC/platelets | CML |
| itchying in shower due to abnormal histamine release | polycythemia |
Created by:
tjamrose
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