WVSOM -- First Aid Leukemia/Lymphoma
Help!
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| How do you differentiate acute from chronic leukemias? | in acute blasts predomiante. Children and elderly in acute.
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| How do you differentiate a leukemoid reaction from CML? | Leukemoid will have incrased leukocyte alkaline phosphatase
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| When do you see auer bodies? | AML
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| What do you see in AML? | a lot of granules and auer rods
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| What are auer rods? | clumped lysosomes
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| M3 | AML
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| t(15;17) | M3 type of AML
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| t(9;22) | Philadelphia chromosome CML
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| t(8;14) | Burkitt's Lymphoma
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| c-myc | Burkitt's lymphoma
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| bcl-2 activation | follicular lymphoma
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| t(14;18) | Follicular Lymphoma
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| t(15;17) | M3 type of AML
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| responsive to all-trans retinoic acid) | M3 type of AML
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| t(11;22) | Ewing's sarcoma
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| t(11;14) | Mantle Cell Lymphoma
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| < 15yo | ALL
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| median onset~ 60yo | AML
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| 30-60 yo | CML
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| > 60 yo | CLL
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| what is there a big risk of in AML? | DIC
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| TRAP | hairy cell leukemia
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| mature B-cell tumor in the elderly. Hairlike projections | Hairy cell leukemia
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| Smudge cells in peripheral blood smear warm antibody autoimmune hemolytic anemia | CLL
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| CD10 | ALL
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| TdT+ marker | ALL
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| mediastinal mass | ALL
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| peroxidase-positive cytoplasmic inclusions | AML
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| fried egg appearance | multiple myeloma
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| BENSE JONES PROTEINS!!! | Multiple myeloma
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| M spike | Multiple myeloma
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| hyper calcemia renal insufficiency anema | multiple myeloma
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| Starry sky | burkitt's lymphoma
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| what does bcl-2 inhibit? | apoptosis
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| HTLV-1 | Adult T cell lymphoma
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| sezary syndrome | mycosis fungoides adults present with cutaneous patches/nodules cutaneous T-cell lymphoma
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| ABD and pelvis lymphadenopathy | diffuse large B-cell lymphoma
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| t(8;14) with HIV | Diffuse large B-cell lymphoma
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| CD30/15 | Reed sternberg cells
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| Most common hodgkin; collagen banding lacunar cells | Nodular sclerosing
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| Prognosis vs number of reed sternberg cells | the more reed sternberg cells the worst prognosis
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| EBV related hodgkin's lymphoma | Lymphocyte rich
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| Byeloid stem cells "Blast crisis" | CML
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| Lymphocytes Non-antibody-producing B cells | CLL
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| Myeloblasts | AML
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| Lymphoblasts (pre-B or pre-T) | ALL
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| abnormal stem cells in bone marrow | leukemia
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| HTLV 2 | hairy Cell Leukemia
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| increased RBC/WBC/Platelets | Polycythemia vera
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| increased platelets >1million platelets | Essential thrombocytosis
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| tear drop cells with big spleen | myelofibrosis
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| decreased RBC increased WBC/platelets | CML
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| itchying in shower due to abnormal histamine release | polycythemia
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