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lecture 11

TermDefinition
heritable variation in populations was a necessary ingredient in natural selection
molecules are specially important for evolution proteins, DNA, RNA
proteins chains of amino acids, polymers formed from 20 diff monomers called amino acids,
proteins act as enzymes that catalyze chemical reactions, structural support, protect, coodinate
several organelles are involved in protein manufacture
protein production transcription and translation
transcription production of RNA from DNA, DNA to RNA
translation ribosomes results in the production of proteins
after transcription RNA travels from the nucleus to a ribosome
ribosomes where proteins are made, rough ER, others float in cytoplasm
smooth ER contains enzymes that produce lipids
rough ER contains ribosomes that produce many kinds of proteins
proteins are finalized and packaged in the golgi apparatus
golgi apparatus finishes, sorts, and ships cell products
vesicles small bubbles made of membrane
DNA deoxyribose nucleic acid, double helix, strings of nucleotides
nucleotide sugar, a phosphate, and a base
adenine (A) thymine (T)
guanine (G) cytosine (T)
each strand of DNA in a double helix is complementary
DNA consists of 2 phosphate backbones joined by a series of bases
mutation any change to the genomic sequence
eukaryotic DNA is organized into chromosomes
histones wound around spool-like proteins
by winding and unwinding DNA around histones cells can expose or hide genes
ploidy number of copies of unique chromosomes in a cell, can vary
in diploids, chromosomes come in homologous pairs
sex chromosome chromosome that pairs during meiosis but differs in copy number between males and females
autosome chromosome that does not differ between sexes
gene segment of DNA nuclotides sequences code for proteins/RNA to regulate expression of other genes
gene expression information from a gene is transformed in to a product
RNA polymerase enzyme that builds the single stranded RNA from the DNA during transcription
codon three bases
mRNA acts as a template for building a protein, which amino acid to add , few direct ribosome to start or stop
hormones molecular signals that flows through the body and can alter the expression of genes
upstream is __ end and downstream is towards the __ end 5', 3'
upstream 5 top 3 bottom, promoter
downstream transcription initiation site, transcription unit, terminator
gene control region upstream section of DNA that includes the promoter region that influence transcription of DNA
repressor protein that binds to a sequence of DNA or RNA and inhibits the expression of one or more genes
transcription factor protein that regulates the expression of a gene by binding to a specific DNA sequence in association with gene sequnce
enhancer short sequence of DNA within gene control region where activator proteins bind to initiate gene expression
microRNA enhance or silence gene translation, can block translation
exons protein coding sequnces for many genes are broken into smaller pieces of coding sequnces
introns noncoding sequences
RNA splicing introns are removed so only exons are included in the mature mRNA and used to dictate what proteins are produces
spliceosome a group of proteins that removes introns from transcripts
the introns are much ____ than the exons longer
RNA splicing can create multiple proteins from a single gene (known as alternative splicing)
prokaryotic gene expression is primarily controlled in transcription
eukaryotic gene expression controls at the levels of everything else
mobile genetic element type of DNA that can move/jump around in the genome and plasmids
plasmid molecule of DNA can replicate indepentently of chromosomal DNA
vertical gene transfer receiving genetic material from an ancestor
horizontal gene transfer transfer fo genetic material between organism without reproduction, can be inherited by descent.
pseudogenes nonfunctional
point mutation single base changes fron one nucleotide to another (substitution)
insertion mutation segment of DNA is inserted into the middle of an existing sequence
deletion mutation segment of DNA is deleted accidentally
frameshift mutation insertion of 1 or 2 bases changes the codon, modifying all amino acids coded downstream
duplication DNA is copied a second time
inversion DNA is flipped around and inserted backwards into original position
chromosome fusion two chromosomes are joined together
aneuploidy chromosomes are duplicated or lost
genome duplication leads to increased ploidy
cis-acting element DNA located near a gene that influences the expression of that gene
trans-acting segment element DNA located away from a gene that code for a protein, microRNA, diffusible molecules
somatic mutation mutation affects cells in the body of an organism, not passed down to offspring in animals
germline mutation affects the gametes of an individual, transmitted from parents to offspring, inheritable genetic variation (passed on)
albinism point mutation
point mutations are relatively common but rare large mutations can change many more base pairs
independent assortment ensures novel combinations of alleles
genes are inherited independently of each other (punnet squares)
recombinations genrates variation
genetic recombination production of gametes, each pair of chromosomes crosses over and exchanges segments of DNA
genotype genetic makeup of an individual
phenotype observable, measurable characteristics as the manifestation of the genotype of an organism
simple polymorphisms can produce differences in phenotype
sometimes a single genotype can produce multiple phenotypes
polyphenic trait single genotype produces multiple phenotypes depending on environment
quantitative traits have continuous distribution of phenotypic variation, generate a normal distribution
QTL analysis can help discover genes influencing quantitative traits
morphogen signaling molecule that flows between nearby cells, alters the expression of targeted genes
phenotypic plasticity changes phenotype produced by a single genotype in different environments, tailors organism to environment
Created by: jcava141
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