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lecture 11
Term | Definition |
---|---|
heritable variation in populations was | a necessary ingredient in natural selection |
molecules are specially important for evolution | proteins, DNA, RNA |
proteins | chains of amino acids, polymers formed from 20 diff monomers called amino acids, |
proteins act as | enzymes that catalyze chemical reactions, structural support, protect, coodinate |
several organelles are | involved in protein manufacture |
protein production | transcription and translation |
transcription | production of RNA from DNA, DNA to RNA |
translation | ribosomes results in the production of proteins |
after transcription | RNA travels from the nucleus to a ribosome |
ribosomes | where proteins are made, rough ER, others float in cytoplasm |
smooth ER | contains enzymes that produce lipids |
rough ER | contains ribosomes that produce many kinds of proteins |
proteins are finalized and packaged in the | golgi apparatus |
golgi apparatus | finishes, sorts, and ships cell products |
vesicles | small bubbles made of membrane |
DNA | deoxyribose nucleic acid, double helix, strings of nucleotides |
nucleotide | sugar, a phosphate, and a base |
adenine (A) | thymine (T) |
guanine (G) | cytosine (T) |
each strand of DNA in a double helix is | complementary |
DNA consists of | 2 phosphate backbones joined by a series of bases |
mutation | any change to the genomic sequence |
eukaryotic DNA is organized into | chromosomes |
histones | wound around spool-like proteins |
by winding and unwinding DNA around histones | cells can expose or hide genes |
ploidy | number of copies of unique chromosomes in a cell, can vary |
in diploids, chromosomes come in | homologous pairs |
sex chromosome | chromosome that pairs during meiosis but differs in copy number between males and females |
autosome | chromosome that does not differ between sexes |
gene | segment of DNA nuclotides sequences code for proteins/RNA to regulate expression of other genes |
gene expression | information from a gene is transformed in to a product |
RNA polymerase | enzyme that builds the single stranded RNA from the DNA during transcription |
codon | three bases |
mRNA | acts as a template for building a protein, which amino acid to add , few direct ribosome to start or stop |
hormones | molecular signals that flows through the body and can alter the expression of genes |
upstream is __ end and downstream is towards the __ end | 5', 3' |
upstream | 5 top 3 bottom, promoter |
downstream | transcription initiation site, transcription unit, terminator |
gene control region | upstream section of DNA that includes the promoter region that influence transcription of DNA |
repressor | protein that binds to a sequence of DNA or RNA and inhibits the expression of one or more genes |
transcription factor | protein that regulates the expression of a gene by binding to a specific DNA sequence in association with gene sequnce |
enhancer | short sequence of DNA within gene control region where activator proteins bind to initiate gene expression |
microRNA | enhance or silence gene translation, can block translation |
exons | protein coding sequnces for many genes are broken into smaller pieces of coding sequnces |
introns | noncoding sequences |
RNA splicing | introns are removed so only exons are included in the mature mRNA and used to dictate what proteins are produces |
spliceosome | a group of proteins that removes introns from transcripts |
the introns are much ____ than the exons | longer |
RNA splicing can | create multiple proteins from a single gene (known as alternative splicing) |
prokaryotic gene expression is primarily controlled in | transcription |
eukaryotic gene expression | controls at the levels of everything else |
mobile genetic element | type of DNA that can move/jump around in the genome and plasmids |
plasmid | molecule of DNA can replicate indepentently of chromosomal DNA |
vertical gene transfer | receiving genetic material from an ancestor |
horizontal gene transfer | transfer fo genetic material between organism without reproduction, can be inherited by descent. |
pseudogenes | nonfunctional |
point mutation | single base changes fron one nucleotide to another (substitution) |
insertion mutation | segment of DNA is inserted into the middle of an existing sequence |
deletion mutation | segment of DNA is deleted accidentally |
frameshift mutation | insertion of 1 or 2 bases changes the codon, modifying all amino acids coded downstream |
duplication | DNA is copied a second time |
inversion | DNA is flipped around and inserted backwards into original position |
chromosome fusion | two chromosomes are joined together |
aneuploidy | chromosomes are duplicated or lost |
genome duplication | leads to increased ploidy |
cis-acting element | DNA located near a gene that influences the expression of that gene |
trans-acting segment element | DNA located away from a gene that code for a protein, microRNA, diffusible molecules |
somatic mutation | mutation affects cells in the body of an organism, not passed down to offspring in animals |
germline mutation | affects the gametes of an individual, transmitted from parents to offspring, inheritable genetic variation (passed on) |
albinism | point mutation |
point mutations are | relatively common but rare large mutations can change many more base pairs |
independent assortment ensures | novel combinations of alleles |
genes are inherited | independently of each other (punnet squares) |
recombinations genrates | variation |
genetic recombination | production of gametes, each pair of chromosomes crosses over and exchanges segments of DNA |
genotype | genetic makeup of an individual |
phenotype | observable, measurable characteristics as the manifestation of the genotype of an organism |
simple polymorphisms can produce | differences in phenotype |
sometimes a single genotype can produce | multiple phenotypes |
polyphenic trait | single genotype produces multiple phenotypes depending on environment |
quantitative traits have | continuous distribution of phenotypic variation, generate a normal distribution |
QTL analysis can help discover | genes influencing quantitative traits |
morphogen | signaling molecule that flows between nearby cells, alters the expression of targeted genes |
phenotypic plasticity | changes phenotype produced by a single genotype in different environments, tailors organism to environment |