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GTF
General Transcrition Factors
Term | Definition |
---|---|
TFIIA | Stabilizes TATA binding protein (TBP) and TFIIB, Stabilizes the TBP-DNA interactions |
TFIIB | Promoter recognition, stabilizes early transcribing complex, Recognizes the TFIIB recognition element (BRE) promoter elements, Helps determine the transcription direction, Mediates RNA pol II binding |
TFIID | Promoter recognition, DNA bending interacts with regulatory factors, Includes the TBP and TAFs subunits, binds to the TATA box via TBP, Binds to the minor groove of DNA and Distorts DNA, Causes local DNA unwinding |
TFIIE | Recruits TFIIH, stimulates strand separation by RNA pol II |
TFIIF | suppresses non-specific DNA binding, captures non-template upon melting, helps RNA pol II bind |
TFIIH | unwinds promoter DNA, phosphorylates C terminal domain (CTD), DNA helicase activity and kinase activity |